Transplantation in mesangiocapillary glomerulonephritis with intramembranous dense 'deposits': Recurrence of disease
| Autor: | Sidney Leibowitz, Michael Bewick, Chisholm S. Ogg, David R. Turner, David J. Evans, J. Stewart Cameron, David Melcher, Anthony Trafford, Paul Sharpstone |
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| Rok vydání: | 1976 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Kidney Glomerulus Graft loss Basement Membrane Complement components Glomerulonephritis Postoperative Complications Recurrence Cadaver medicine Humans Transplantation Homologous Tubular basement membrane Child Gynecology medicine.diagnostic_test business.industry Complement C3 medicine.disease Kidney Transplantation Capillaries Immunoglobulin A Transplantation Immunoglobulin M Nephrology Intramembranous ossification Renal biopsy business |
| Zdroj: | Kidney International. 9:439-448 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/ki.1976.54 |
| Popis: | Transplantation in mesangiocapillary glomerulonephritis with intramembranous dense "deposits": Recurrence of disease. Six patients with mesangiocapillary glomerulonephritis and intramembranous dense "deposits" developed terminal renal failure and were transplanted, three from living and three from cadaver donors. Eight renal biopsy specimens were obtained from five of the grafts, from 1 to 26 months following transplantation. All six biopsy specimens taken later than seven months following the graft showed recurrence of dense intramembranous "deposits" in the basement membranes of glomeruli, and of Bowman's capsule and tubular basement membrane in five. Recurrence of "deposits" was associated with deposition of C3 on immunofluorescent study in all but one specimen; in addition, lgM was found in two specimens, but lgG and early complement components were absent. Only two patients, however, showed glomerular proliferation associated with profuse proteinuria. In the other subjects the recurrence of the "deposit" was not associated with clinical findings. Graft loss, which occurred in two patients, was predominantly from rejection. Transplantation dans la glomerulopathie a depots denses intra-membraneux: Recidive de la maladie. Six malades atteints de glomerulopathie a depots denses intra-membraneux ont atteint le stade d'insuffisance renale terminale et ont ete transplantes. Trois d'entre eux ont recu un rein de donneur vivant et les trois autres un rein de cadavre. Huit biopsies renales ont ete realisees sur cinq de ces transplants un a trente-six mois apres la transplantation. Les six biopsies prelevees apres le septieme mois de la transplantation montrent toutes la recidive des depots denses intra-membraneux dans les glomerules et cinq d'entre elles montrent aussi ces depots dans la capsule de Bowman et la membrane basale tubulaire. La recidive des depots est associee a la presence de C3, revelee par l'etude en immunofluorescence, dans toutes les biopsies sauf une. De plus, de l'IgM a ete trouvee dans deux biopsies mais l'IgG et les facteurs precoces du complement sont absents. Deux malades seulement ont une proliferation glomerulaire associee a une proteinurie importante. Chez les autres, la recidive des depots n'est pas contemporaine de manifestations cliniques. La destruction du greffon, qui est survenue chez deux malades, a ete essentiellement le fait du rejet. |
| Databáze: | OpenAIRE |
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