Adipose crosstalk with other cell types in health and disease
| Autor: | Chan Hee J. Choi, Paul Cohen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell type Adiponectin Leptin Adipokine Adipose tissue Cell Biology Biology Microvesicles Cell biology 03 medical and health sciences Crosstalk (biology) 030104 developmental biology 0302 clinical medicine Adipose Tissue Cardiovascular Diseases 030220 oncology & carcinogenesis Immunology Diabetes Mellitus Animals Humans Secretion Obesity Signal Transduction |
| Zdroj: | Experimental Cell Research. 360:6-11 |
| ISSN: | 0014-4827 |
| DOI: | 10.1016/j.yexcr.2017.04.022 |
| Popis: | In addition to storing and mobilizing energy, adipocytes secrete circulating factors to signal to other tissues and coordinate energy metabolism. These functions can become disrupted in the setting of obesity, contributing to the development of diabetes, cardiovascular disease, and cancer. Since the discovery of leptin and adiponectin, an increasing number of adipokines have been identified and their functions elucidated. More recent studies have highlighted other modes by which adipose tissue can participate in crosstalk with other cell types and tissues. These modes of communication, which are reviewed here, include the secretion of enzymes, lipid species, and exosomes. Advances in profiling technology suggest that a substantial number of adipose-derived factors remain to be characterized. Further advances in this growing field are likely to provide important basic insights into the molecular control of metabolism. |
| Databáze: | OpenAIRE |
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