Neural crest origin of clear cell sarcoma of tendons and aponeuroses. Ultrastructural and enzyme cytochemical study of human and nude mouse-transplanted tumours
| Autor: | Susumu Tamai, Yoshio Mii, Kanya Hohnoki, Kayoko Dohmae, Takahisa Yamanouchi, Yoichi Konishi, Yoshizumi Miyauchi, Hiroshi Maruyama, Masahiro Tsutsumi |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Pathology
medicine.medical_specialty Mice Nude Histogenesis Pathology and Forensic Medicine Cell Line Tendons Mice Nude mouse Muscular Diseases medicine Animals Humans Molecular Biology Melanosome biology Histocytochemistry fungi Neural crest Soft tissue Sarcoma Cell Biology General Medicine biology.organism_classification medicine.disease Microscopy Electron Cell culture Neural Crest Clear-cell sarcoma Sarcoma Experimental Neoplasm Transplantation |
| Zdroj: | Virchows Archiv. A, Pathological anatomy and histopathology. 415(1) |
| ISSN: | 0174-7398 |
| Popis: | In order to clarify the histogenesis of clear cell sarcoma of tendons and aponeuroses (CCS), two cases of human and one nude mouse-transplanted CCS line were studied using an ultrastructural and enzyme cytochemical approach. Most of the tumour cells obtained from the primary and transplanted CCS demonstrated melanosomes in various stages of development within the cytoplasm, whereas no melanosomes could be identified in the metastatic CCS. However, cholinesterase and tyrosinase activities could be demonstrated not only in the melanotic primary and transplanted CCS but also in the amelanotic metastatic CCS. The results therefore support the hypothesis that CCS is a soft tissue tumour derived from the neural crest. |
| Databáze: | OpenAIRE |
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