Effect of short-term oral and inhaled corticosteroids on airway inflammation and responsiveness in a feline acute asthma model
| Autor: | Cécile Clercx, Frédéric Snaps, Jérôme Leemans, Pascal Gustin, Nathalie Kirschvink |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Prednisolone Anti-Inflammatory Agents Administration Oral Cat Diseases Fluticasone propionate Administration Inhalation medicine Animals Albuterol Prospective Studies Ascaris suum Fluticasone Asthma Feline asthma Fluticasone-Salmeterol Drug Combination Cross-Over Studies General Veterinary medicine.diagnostic_test business.industry Allergens respiratory system medicine.disease Bronchodilator Agents respiratory tract diseases Androstadienes Drug Combinations Bronchoalveolar lavage Antigens Helminth Anesthesia Cats Female Animal Science and Zoology Salmeterol business medicine.drug |
| Zdroj: | The Veterinary Journal. 192:41-48 |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/j.tvjl.2011.01.020 |
| Popis: | The objective of this study was to investigate whether high-dose inhaled fluticasone propionate (FP), alone or in combination with salmeterol (SAL), is as effective as oral prednisolone in reducing airway inflammation and obstruction in cats with experimentally-induced acute asthma. Six cats sensitised to Ascaris suum (AS) were enrolled in a prospective controlled therapeutic trial and underwent four aerosol challenges, at 1-month intervals with AS allergen. The allergen - stimulated animals received four consecutive days treatment with either oral prednisolone at 1mg/kg twice daily, 500 μg of FP inhaled twice daily, or a combination of FP/SAL at 500 μg/50 μg inhaled twice daily, respectively, according to a randomised cross-over design. Treatment-related changes in lung function, airway responsiveness (AR) and bronchoalveolar lavage fluid (BALF) cytology were assessed. Barometric whole-body plethysmography (BWBP) was used for the assessment of respiratory variables and AR. No significant differences in respiratory rate or Penh (an estimate of airflow limitation measured by BWBP) were detected among treatment groups. Allergen-induced airway hyper-responsiveness was significantly inhibited by all three steroid treatments (P |
| Databáze: | OpenAIRE |
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