Risk factors for sexual dysfunction after rectal cancer surgery in 948 consecutive patients: A prospective cohort study

Autor: Kai Li, Xiaobo He, Shilun Tong, Yongbin Zheng
Rok vydání: 2021
Předmět:
Adult
Male
medicine.medical_specialty
Multivariate analysis
Organoplatinum Compounds
Colorectal cancer
Leucovorin
Adenocarcinoma
030230 surgery
Logistic regression
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Risk Factors
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Prospective Studies
Risk factor
Prospective cohort study
Capecitabine
Digestive System Surgical Procedures
Proctectomy
Radiotherapy
Rectal Neoplasms
business.industry
Age Factors
General Medicine
Middle Aged
medicine.disease
Neoadjuvant Therapy
Oxaliplatin
Sexual Dysfunction
Physiological
Logistic Models
Sexual dysfunction
Oncology
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
Multivariate Analysis
Rectal cancer surgery
Female
Surgery
Fluorouracil
medicine.symptom
Sexual function
business
Zdroj: European Journal of Surgical Oncology. 47:2087-2092
ISSN: 0748-7983
DOI: 10.1016/j.ejso.2021.03.251
Popis: Sexual dysfunctions seriously affect the quality of life of patients. The aim of this study was to identify the risk factors for sexual dysfunction after rectal cancer surgery.A total of 948 consecutive patients undergoing rectal cancer radical resection were included between January 2012 and August 2019. The sexual functions were evaluated by the 5-item version of the International Index of Erectile Function (IIEF-5) in men and Index of Female Sexual Function (IFSF) in women at 12 months postoperatively.Postoperative sexual dysfunction was observed in 228 patients with rectal cancer (24.05%), which included 150 cases in male patients (25.0%) and 78 cases in female patients (22.5%). A multivariate logistic regression analysis results showed that age ≥45 years old (OR = 1.72, p = 0.001), tumor below the peritoneal reflection (OR = 1.64, p = 0.005), receiving preoperative radiotherapy (OR = 4.12, p 0.001) and undergoing abdominoperineal resection (APR), intersphincteric resection (ISR) and Hartmann surgery (OR = 2.43, p 0.001) were the independent risk factors of sexual dysfunction for patients with rectal cancer.Age ≥45 years old, tumors below the peritoneal reflection, receiving preoperative radiotherapy, and undergoing APR, ISR and Hartmann surgery were the independent risk factors of sexual dysfunction. Patients should be informed about the sexual dysfunctions in the pre-operative consultations. More attention should be paid to intraoperative pelvic autonomic nerve preservation on rectal cancer patients with these risk factors for clinic surgeons.
Databáze: OpenAIRE
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