Activation of stem cell up-regulation/mobilization: a cardiovascular risk in both mice and humans with implications for liver disease, psoriasis and SLE

Autor: Andrew R Forauer, John M Gemery, Eric K Hoffer
Rok vydání: 2019
Předmět:
Apolipoprotein E
HDL
Mice
Knockout
ApoE
Endocrinology
Diabetes and Metabolism
SLE
Review
030204 cardiovascular system & hematology
03 medical and health sciences
Liver disease
0302 clinical medicine
Downregulation and upregulation
Cell Movement
Risk Factors
Psoriasis
Animals
Humans
Lupus Erythematosus
Systemic
Medicine
Pharmacology (medical)
030212 general & internal medicine
ATP Binding Cassette Transporter
Subfamily G
Member 1
Mobilization
biology
business.industry
Vascular disease
Liver Diseases
Stem Cells
Public Health
Environmental and Occupational Health
vascular disease
psoriasis
Hematology
General Medicine
Prognosis
medicine.disease
Disease Models
Animal
Phenotype
Cardiovascular Diseases
ABCA1
Immunology
Disease Progression
biology.protein
Inflammation Mediators
Stem cell
liver disease
Cardiology and Cardiovascular Medicine
business
ATP Binding Cassette Transporter 1
Zdroj: Vascular Health and Risk Management
ISSN: 1178-2048
DOI: 10.2147/vhrm.s207161
Popis: Experimentally induced injury triggers up-regulation and mobilization of stem cells in Apoe -/- mice that causes accelerated atherosclerosis. Abca1 -/- Abcg1-/- mice have chronic activation of stem cell up-regulation/mobilization and accelerated atherosclerosis. In addition, the Abca1 -/- Abcg1-/- mice have elevation of serum cytokines G-CSF, IL-17 and IL-23, each necessary for stem cell mobilization. IL-17 and IL-23 are elevated in two human illnesses that have cardiovascular (CV) risk independent of traditional risk factors—SLE and psoriasis. Serum G-CSF, which can be elevated in liver disease, predicts major adverse cardiovascular events in humans. These serum cytokine elevations suggest activation of the stem cell mobilization mechanism in humans that results, as in mice, in accelerated atherosclerosis. Efforts to reduce CV disease in these patient populations should include mitigation of the diseases that trigger stem cell mobilization. Since activation of the stem cell up-regulation/mobilization mechanism appears to accelerate human atherosclerosis, use of stem cells as therapy for arterial occlusive disease should distinguish between direct administration of stem cells and activation of the stem cell up-regulation/mobilization mechanism.
Databáze: OpenAIRE
Externí odkaz: