Effect of Hypothermia on Serum Myelin Basic Protein and Tumor Necrosis Factor-α in Neonatal Hypoxic-Ischemic Encephalopathy
| Autor: | Pengshun Ren, Lianxiang Li, Haihua Huo, Junxia Song, Qiuli Wang, Sujing Wu, Junqin Li, Hongyan Lv |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Encephalopathy Hypothermia Gastroenterology Neuroprotection law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Hypothermia Induced 030225 pediatrics Internal medicine medicine Humans Tumor necrosis factor α biology business.industry Tumor Necrosis Factor-alpha Infant Newborn Obstetrics and Gynecology Infant Myelin Basic Protein medicine.disease Neonatal Hypoxic Ischemic Encephalopathy Myelin basic protein Pediatrics Perinatology and Child Health Hypoxia-Ischemia Brain biology.protein Tumor necrosis factor alpha medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | American journal of perinatology. 39(12) |
| ISSN: | 1098-8785 |
| Popis: | Objective Multiple randomized controlled trials have shown that hypothermia is a safe and effective treatment for neonatal moderate or severe hypoxic-ischemic encephalopathy (HIE). The neuroprotective mechanisms of hypothermia need further study. The aim of this study was to investigate the effect of hypothermia on the serum levels of myelin basic protein (MBP) and tumor necrosis factor-α (TNF-α) as well as neurodevelopmental outcomes in neonatal HIE. Study Design Eighty-five neonates with moderate-to-severe HIE were divided into a hypothermia group (n = 49) and a control group (n = 36). Serum levels of MBP and TNF-α within 6 hours after birth and after 3 days of treatment were determined by enzyme-linked immunosorbent assay, and neurodevelopmental outcome at the age of 12 to 15 months was assessed by using the Gesell development scale. Results After 3 days of treatment, serum levels of MBP and TNF-α in the control group were not significantly different from levels before treatment (p > 0.05), and serum levels of MBP and TNF-α in the hypothermia group were significantly lower than levels before treatment (p Conclusion Hypothermia can reduce serum levels of MBP and TNF-α in neonates with HIE. Inhibiting the release of TNF-α may be one of the mechanisms by which hypothermia protects the myelin sheath. Key Points |
| Databáze: | OpenAIRE |
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