Comparative examinations of 99mTc-DMS preparations obtained by labelling dimercaptosuccinate kits with different formulations. II. Comparison of chemical and biological characteristics of TcP-5 and MPI kits
| Autor: | Nada Vanlić-Razumenić |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Vinca Post injection Kidney chemistry.chemical_compound Biological property Labelling medicine Animals Radiology Nuclear Medicine and imaging Tissue Distribution Sulfhydryl Compounds Radionuclide Imaging Aqueous solution Chromatography biology business.industry Technetium General Medicine biology.organism_classification Rats Paper chromatography medicine.anatomical_structure chemistry Tin Methanol Reagent Kits Diagnostic business Succimer |
| Zdroj: | Nuklearmedizin. Nuclear medicine. 20(1) |
| ISSN: | 0029-5566 |
| Popis: | The chemical and biological properties of two freeze-dried DMS kits for labelling with WmTc (Tc P-5, manufactured by Boris Kidric Institute, Vinca, and TCK-12, by CIS, Saclay) were compared. A method for the determination of the radiochemical composition of the injection solution is proposed: ascending Whatman 3 1 paper chromatography in 50% aqueous methanol. The chromatographic results correspond to the biologic activity of the preparations. The biodynamics of both radiopharmaceuticals were determined at intervals in rats. Maximum renal concentrations were achieved at 3 - 4 hrs post injection (52 % kidney and 3 % liver uptake for Tc P-5; 59 % kidney and 6 - 8 % liver uptake for TCK-12). The bench-lifes of the injection solutions were compared by determining organ distribution after standing of the solutions for 0, 2 and 4 hrs. The Tc P-5 preparation was more stable, since the renal and hepatic concentrations were nearly constant. On the other hand, the hepatic concentration of TCK-12 was increasing during aging of the solution with a simultaneous decrease in renal concentration. |
| Databáze: | OpenAIRE |
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