The effect of selective bowel decontamination on the pharmacokinetics of mycophenolate mofetil in liver transplant recipients
| Autor: | Bent Adel Hansen, Mette Rindom Nørrelykke, Allan Rasmussen, Lars E. Schmidt, Henrik E. Poulsen |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Time Factors Biological Availability Pharmacology Mycophenolate Mycophenolic acid Deglucuronidation Pharmacokinetics medicine Humans Prospective Studies Active metabolite Aged Transplantation Hepatology business.industry Prodrug Middle Aged Mycophenolic Acid Bioavailability Anti-Bacterial Agents Liver Transplantation Intestines Regimen Surgery Female business Immunosuppressive Agents medicine.drug |
| Zdroj: | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 7(8) |
| ISSN: | 1527-6465 |
| Popis: | Mycophenolate mofetil (MMF) is a prodrug immunosuppressant with a high oral bioavailability. Enterohepatic cycling of a glucuronide derivative of MMF contributes substantially to the bioavailability, but is dependent on bacterial deglucuronidation by intestinal flora. This study aims to determine whether an antibiotic regimen with activity against such organisms reduces the bioavailability of MMF by impairing enterohepatic cycling. In a prospective trial, 6 liver transplant recipients were administered MMF and a 21-day antibiotic regimen for selective bowel decontamination (SBD). Time-concentration profiles of the pharmacologically active metabolite, mycophenolic acid (MPA), were obtained during and after the SBD regimen. The bioavailability of MPA was reduced during compared with after the regimen (14.5 +/- 3.5 v 21.1 +/- 9.8 mg. h/mL; P =.07). The most pronounced contribution to this reduction was observed from 6 hours onward (2.4 +/- 1.4 v 5.6 +/- 4.4 mg. h/mL; P |
| Databáze: | OpenAIRE |
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