Stereotactic thalamotomy in tremor-dominant Parkinson's disease: An H215O PET motor activation study
| Autor: | M. Samuel, Adrian J. Wills, David J. Brooks, David G. T. Thomas, Andres O. Ceballos-Baumann, Henning Boecker, C. David Marsden |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Parkinson's disease medicine.medical_treatment Thalamus Neurological disorder Premotor cortex Central nervous system disease Degenerative disease Tremor medicine Humans Aged business.industry Thalamotomy Brain Parkinson Disease Body movement Middle Aged medicine.disease medicine.anatomical_structure Neurology Female Neurology (clinical) business Neuroscience Tomography Emission-Computed |
| Zdroj: | Annals of Neurology. 41:108-111 |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.410410118 |
| Popis: | Stereotactic thalamotomy is an effective treatment for severe drug-resistant tremor. The thalamus, however, facilitates motor activity, and thalamotomy would be predicted to inhibit movement-associated cortical activation. Two tremulous parkinsonian patients were studied with H 2 15 O positron emission tomography before and after left ventralis intermedius thalamotomy. Subjects were scanned at rest and during performance of externally paced joystick movements in freely selected directions with the right hand. Thalamotomy relieved tremor but, as predicted, led to decreased activation of the left sensorimotor cortex, lateral premotor cortex, and parietal area 7 on hand movement. |
| Databáze: | OpenAIRE |
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