DHEA improves symptomatic treatment of moderately and severely impaired MPTP monkeys
| Autor: | Paul J. Bédard, Nancy Bélanger, Laurent Grégoire, Thérèse Di Paolo |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Dyskinesia
Drug-Induced endocrine system Aging medicine.medical_specialty Parkinson's disease Dehydroepiandrosterone Motor Activity Inhibitory postsynaptic potential Severity of Illness Index Antiparkinson Agents Levodopa chemistry.chemical_compound Parkinsonian Disorders Dopamine Internal medicine Severity of illness polycyclic compounds medicine Animals business.industry General Neuroscience MPTP medicine.disease nervous system diseases Macaca fascicularis Endocrinology chemistry Dyskinesia 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine GABAergic Female Neurology (clinical) Geriatrics and Gerontology medicine.symptom business human activities hormones hormone substitutes and hormone antagonists Developmental Biology medicine.drug |
| Zdroj: | Neurobiology of Aging. 27:1684-1693 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2005.09.028 |
| Popis: | The steroid dehydroepiandrosterone (DHEA) is abundant in men and women and decreases rapidly during aging. Parkinson's disease (PD) is the second most common neurodegenerative disorder just behind Alzheimer. l-3,4-Dihydroxyphenylalanine (l-Dopa) therapy remains the most effective treatment but many patients develop motor complications. This study investigated the acute effect of DHEA alone and with l-Dopa in 12 females monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to model PD. DHEA administration alone improved the mean parkinsonian score at 1, 5 and 15mg/kg in moderately and severely impaired MPTP monkeys and increased blood DHEA concentrations. DHEA with a low dose of l-Dopa increased the l-Dopa effect in moderately and severely impaired MPTP monkeys. DHEA lengthened duration of the effect of the low dose of l-Dopa by 15-45min. DHEA at 1, 5 and 15mg/kg combined with a high dose of l-Dopa did not increase dyskinesias. DHEA could act by reducing inhibitory GABAergic activity in the striatal output pathways. DHEA could also be metabolized into estradiol in the brain and increase acutely dopamine activity. |
| Databáze: | OpenAIRE |
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