Antimicrobial susceptibility patterns and resistance trends of staphylococcus aureus and coagulase-negative staphylococci strains isolated from ocular infections
| Autor: | Matteo Fallico, Giovanni Boccia, Teresio Avitabile, Francesco Petrillo, Maria Consiglia Trotta, Veronica Folliero, Michele Rinaldi, Michele Reibaldi, Biagio Santella, Federica Maria Di Lella, Danilo Pignataro, Michele D'Amico, Maria Teresa Della Rocca, Marilena Galdiero, Niccolò Castellino, Gianluigi Franci, Guglielmo Parisi |
|---|---|
| Přispěvatelé: | Petrillo, F., Pignataro, D., Di Lella, F. M., Reibaldi, M., Fallico, M., Castellino, N., Parisi, G., Trotta, M. C., D'Amico, M., Santella, B., Folliero, V., Della Rocca, M. T., Rinaldi, M., Franci, G., Avitabile, T., Galdiero, M., Boccia, G. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) genetic structures medicine.drug_class 030106 microbiology Antibiotics Drug resistance RM1-950 medicine.disease_cause Biochemistry Microbiology Article 03 medical and health sciences Hospital 0302 clinical medicine Antibiotic resistance Medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Eye infection business.industry Bacterial Eye infections Hospitals Methicillin-resistant staphylococcus aureus Sulfamethoxazole Methicillin-resistant Staphylococcus aureus Trimethoprim Infectious Diseases 030221 ophthalmology & optometry Therapeutics. Pharmacology sense organs Coagulase business medicine.drug |
| Zdroj: | Antibiotics Antibiotics, Vol 10, Iss 527, p 527 (2021) Volume 10 Issue 5 |
| Popis: | Ocular bacterial infections represent a serious problem that affecting people of all age and genders. These infections can lead to visual impairment and blindness if not properly treated. The current study evaluates the antimicrobial resistance profiles and the resistance trend of both Staphylococcus aureus (S. aureus) and coagulase-negative staphylococci (CoNS), the main pathogens involved in eye infections. A total of 322 isolates of S. aureus and CoNS, were collected from patients with bacterial conjunctivitis and keratitis at the “Luigi Vanvitelli” University Hospital of Campania in Naples, Italy, between 2017 and 2020. The isolated bacteria showed a high percentage of resistance to methicillin and other antibiotics commonly used for the treatment of ocular infections. Trends in antibiotic resistance were not encouraging, recording—especially among CoNS strains—an increase of more than 20% in resistance to methicillin and aminoglycosides during the study period. Instead, the resistance rates to tetracycline had a significant decrease in CoNS isolates while no changes in their susceptibility to fluoroquinolones and macrolides were observed. However, all isolates showed no resistance to trimethoprim/sulfamethoxazole and chloramphenicol. In this scenario, preventive identification of the infection causative agents and the evaluation of the antimicrobial susceptibility patterns are essential to set up an ocular infection effective drug treatment and also prevent antibiotic resistance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|