Transferrin-inspired vehicles based on pH-responsive coordination bond to combat multidrug-resistant breast cancer
| Autor: | Peng-Fei Cui, Yu-Xin Zhou, Na Lu, Yu-Jing He, Yong Zhu, Lei Xing, Jin-Yuan Lyu, Hu-Lin Jiang, Jian-Bin Qiao, Mei Zhang, Jia-Liang Zhang, Cheng-Qiong Luo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Biocompatibility Biophysics Mice Nude Bioengineering Nanotechnology Breast Neoplasms 02 engineering and technology 010402 general chemistry Endocytosis 01 natural sciences Biomaterials In vivo Cell Line Tumor medicine Animals Humans Doxorubicin Breast Bovine serum albumin chemistry.chemical_classification Mice Inbred BALB C Antibiotics Antineoplastic biology Transferrin Serum Albumin Bovine Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Drug Resistance Multiple 0104 chemical sciences Targeted drug delivery chemistry Biochemistry Mechanics of Materials Drug Resistance Neoplasm Delayed-Action Preparations Drug delivery Ceramics and Composites biology.protein Nanoparticles Cattle Female 0210 nano-technology medicine.drug Histamine |
| Zdroj: | Biomaterials. 113 |
| ISSN: | 1878-5905 |
| Popis: | A novel biomimetic drug delivery system (BDDS) inspired by the pH-dependent ferric ion-transport and release manner of transferrin (Tf) was developed for combating multidrug-resistant breast cancer. Tf-inspired carrier was synthesized by modifying bovine serum albumin (BSA) with histamine (HA) through amide reaction to provide superior specific coordination sites for ferric ion-drug complexes, and self-assembled into nanoparticles (NPs) induced by coordination bond. Tf-inspired NPs were prepared via environment-friendly method, and well redispersed in saline after lyophilization. When internalized into tumor cells by SPARC (secreted protein acidic and rich in cysteine) mediated endocytosis, Tf-inspired NPs bypassed and decreased the P-glycoprotein-mediated drug efflux and led to more effective treatment of multidrug-resistant breast cancer compared with free drugs both in vitro and in vivo due to the enhanced cellular uptake and rapid pH-responsive drug release. Moreover, Tf-inspired NPs exhibited good biocompatibility and low systemic toxicity. Thus, our results demonstrate that Tf-inspired NPs based on coordination bond represent as a smart drug delivery strategy to combat multidrug-resistant cancer and have great potential for clinical applications in cancer therapy. |
| Databáze: | OpenAIRE |
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