Higher risk of myocardial injury in chest pain patients with elevated red blood cell distribution width
| Autor: | Zhen-Zhen Cai, Xue-Lian Xiao, Jia Wei, Jian Xu, Qin Ye, Rui-Xia Yang, Min Wang, Zhong-Jian Zhao, Xiao-Ling Zang, Li Jiang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Erythrocyte Indices Male Chest Pain medicine.medical_specialty Erythrocytes Adolescent Clinical Biochemistry Myocardial Infarction 030204 cardiovascular system & hematology Age and sex Chest pain Biochemistry Coronary artery disease Young Adult 03 medical and health sciences 0302 clinical medicine Troponin T Risk Factors Internal medicine Humans Medicine 030212 general & internal medicine Myocardial infarction Aged Retrospective Studies Aged 80 and over Receiver operating characteristic business.industry Myocardium Biochemistry (medical) Area under the curve Red blood cell distribution width General Medicine Middle Aged medicine.disease Blood Cell Count Quartile Cardiology Female medicine.symptom business |
| Zdroj: | Clinica Chimica Acta. 481:121-125 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2018.03.001 |
| Popis: | Background High level of red blood cell distribution width (RDW) has been associated with adverse outcomes in coronary artery disease patients. We aimed to investigate the relationship between RDW and the risk of myocardial injury in chest pain patients. Methods and Results We retrospectively reviewed 2078 chest pain patients with suspected acute myocardial infarction. Myocardial injury was defined as high-sensitivity cardiac troponin T (hs-cTnT) >14 ng/L. RDW was associated with hs-cTnT (r = 0.607) and the risk of myocardial injury stepwise increased across increasing RDW quartiles in all subgroups based on age and sex. The receiver operating characteristic curve analysis was calculated to assess the elevated RDW to predict myocardial injury, with the cutoff value of 13.25%. RDW had a high sensitivity (78.10%), specificity (87.44%), as well as positive predictive value (77.48%). The area under the curve (AUC) for all patients was 0.88 (95%CI 0.87, 0.90) and there is no statistical significant in AUCs for all subgroups. Conclusions Elevated RDW was significantly associated with a higher risk of myocardial injury in chest pain patients with potential acute myocardial infarction. The RDW may be helpful to identify myocardial injury in such patients. |
| Databáze: | OpenAIRE |
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