Disproportionate burden of coronavirus disease 2019 among racial minorities and those in congregate settings among a large cohort of people with HIV

Autor: Sarimer M. Sánchez, Kimon C. Zachary, Kevin L. Ard, Rajesh T. Gandhi, Wei He, Nesli Basgoz, Arthur Y. Kim, Rocío M. Hurtado, Eric A. Meyerowitz, Jacqueline T. Chu, Catherine K. Lee, Bisola O. Ojikutu, Greg Robbins, Theresa Minukas, Virginia A. Triant, Sandra B Nelson
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
HIV Infections
Disease
Comorbidity
Cohort Studies
0302 clinical medicine
Cost of Illness
Risk Factors
Pandemic
Immunology and Allergy
030212 general & internal medicine
education.field_of_study
Hispanic or Latino
Middle Aged
Infectious Diseases
Massachusetts
Cohort
racial disparities
Female
Clinical Science: Special Section: Covid-19 among People Living with HIV
Coronavirus Infections
Cohort study
Adult
severe acute respiratory distress syndrome coronavirus 2
Immunology
Population
Pneumonia
Viral
03 medical and health sciences
Betacoronavirus
coronavirus disease 2019
Environmental health
medicine
Humans
education
Pandemics
Aged
business.industry
SARS-CoV-2
pandemic
Outbreak
COVID-19
HIV
medicine.disease
Obesity
Black or African American
030104 developmental biology
business
congregate setting
Zdroj: AIDS (London, England)
AIDS
ISSN: 1473-5571
0269-9370
Popis: BACKGROUND: Many people living with HIV (PLWH) have comorbidities which are risk factors for severe coronavirus disease 2019 (COVID-19) or have exposures that may lead to acquisition of severe acute respiratory distress syndrome coronavirus 2. There are few studies, however, on the demographics, comorbidities, clinical presentation, or outcomes of COVID-19 in people with HIV. OBJECTIVE: To evaluate risk factors, clinical manifestations, and outcomes in a large cohort of PLWH with COVID-19. METHODS: We systematically identified all PLWH who were diagnosed with COVID-19 at a large hospital from 3 March to 26 April 2020 during an outbreak in Massachusetts. We analyzed each of the cases to extract information including demographics, medical comorbidities, clinical presentation, and illness course after COVID-19 diagnosis. RESULTS: We describe a cohort of 36 PLWH with confirmed COVID-19 and another 11 patients with probable COVID-19. Almost 85% of PLWH with confirmed COVID-19 had a comorbidity associated with severe disease, including obesity, cardiovascular disease, or hypertension. Approximately 77% of PLWH with COVID-19 were non-Hispanic Black or Latinx whereas only 40% of the PLWH in our clinic were Black or Latinx. Nearly half of PLWH with COVID-19 had exposure to congregate settings. In addition to people with confirmed COVID-19, we identified another 11 individuals with probable COVID-19, almost all of whom had negative PCR testing. CONCLUSION: In the largest cohort to date of PLWH and confirmed COVID-19, almost all had a comorbidity associated with severe disease, highlighting the importance of non-HIV risk factors in this population. The racial disparities and frequent link to congregate settings in PLWH and COVID-19 need to be explored urgently.
Databáze: OpenAIRE
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