Socioeconomic Disparities in Non-Small Cell Lung Cancer With Brain Metastases at Presentation: A Population-Based Study
| Autor: | Courtney Hentz, Vikram C. Prabhu, Jigisha P. Thakkar, Kathy S. Albain, Ignacio Jusué-Torres, Edward Melian, Jehad Zakaria, Alicia Hulbert |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms Population Cohort Studies Carcinoma Non-Small-Cell Lung Internal medicine Epidemiology medicine Humans Healthcare Disparities Lung cancer education Socioeconomic status Aged Proportional Hazards Models Aged 80 and over education.field_of_study Brain Neoplasms business.industry Middle Aged medicine.disease Survival Analysis Socioeconomic Factors Quartile Income Household income Female Surgery Neurology (clinical) business SEER Program Brain metastasis Cohort study |
| Zdroj: | World Neurosurgery. 154:e236-e244 |
| ISSN: | 1878-8750 |
| DOI: | 10.1016/j.wneu.2021.07.024 |
| Popis: | Objective/Background The purpose of this study was to characterize the impact of household income disparities in the survival of patients with non-small cell lung cancer (NSCLC) presenting with brain metastasis on a population-based level. Methods This is a population-based cohort study using the Surveillance, Epidemiology, and End Results (SEER) database from 2010–2016 including 15,808 NSCLC patients presenting with brain metastasis. Results This study comprises 15,808 adult patients with NSCLC presenting with brain metastases having an age range 64 ± 10 years with 51% male, 76% white, 52% married, 61% insured, and with 85% of lung adenocarcinoma histopathology. The 1-, 2- and 5-year survival rates for living in the lower household income quartile were 21%, 10%, and 3%, respectively, for the second quartile 24%, 10%, and 3%; for the third quartile 28%, 14%, and 4%; and for the top quartile 31%, 17%, and 4%, respectively. Multivariate Cox proportional hazard analysis showed that living in a higher quartile household income county is associated with increased survival (P Conclusions This population-based study suggests that living in higher median household income counties is associated with increased survival time and reduced risk of mortality for patients with NSCLC who have brain metastases present at diagnosis, independent of other factors. These findings underscore the importance of ensuring adequate and easy access to care for all patients, irrespective of their economic background. |
| Databáze: | OpenAIRE |
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