Susceptibility to infection with Borrelia afzelii and TLR2 polymorphism in a wild reservoir host
| Autor: | Dolores Genné, Tapio Mappes, Andrea Gomez-Chamorro, Esa Koskela, Anouk Sarr, Claire Cayol, Florian Battilotti, Maarten J. Voordouw, Nathalie Boulanger |
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| Přispěvatelé: | Virulence bactérienne précoce : fonctions cellulaires et contrôle de l'infection aiguë et subaiguë, Université de Strasbourg (UNISTRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Nymph 0301 basic medicine metsämyyrä lcsh:Medicine Tick Borrelia afzelii medicine.disease_cause infektiot genotyyppi Article 03 medical and health sciences Ticks 0302 clinical medicine Lyme disease Borrelia burgdorferi Group Polymorphism (computer science) Genotype Genetic variation parasitic diseases isäntäeläimet Immunogenetics medicine Animals immuniteetti Genetic Predisposition to Disease lcsh:Science Disease Reservoirs Genetics Lyme Disease Polymorphism Genetic Multidisciplinary Innate immune system biology Arvicolinae lcsh:R Ecological genetics medicine.disease biology.organism_classification bacterial infections and mycoses Toll-Like Receptor 2 Borrelia-bakteerit Bank vole 030104 developmental biology [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Female lcsh:Q 030217 neurology & neurosurgery Clethrionomys |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-43160-3⟩ C:\Users\Xavier\Zotero\storage\UAY8B98P\Gomez-Chamorro et al.-2019-Susceptibility to infection with Borrelia afzelii .pdf Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-43160-3⟩ |
| Popis: | The study of polymorphic immune genes in host populations is critical for understanding genetic variation in susceptibility to pathogens. Controlled infection experiments are necessary to separate variation in the probability of exposure from genetic variation in susceptibility to infection, but such experiments are rare for wild vertebrate reservoir hosts and their zoonotic pathogens. The bank vole (Myodes glareolus) is an important reservoir host of Borrelia afzelii, a tick-borne spirochete that causes Lyme disease. Bank vole populations are polymorphic for Toll-like receptor 2 (TLR2), an innate immune receptor that recognizes bacterial lipoproteins. To test whether the TLR2 polymorphism influences variation in the susceptibility to infection with B. afzelii, we challenged pathogen-free, lab-born individuals of known TLR2 genotype with B. afzelii-infected ticks. We measured the spirochete load in tissues of the bank voles. The susceptibility to infection with B. afzelii following an infected tick bite was very high (95%) and did not differ between TLR2 genotypes. The TLR2 polymorphism also had no effect on the spirochete abundance in the tissues of the bank voles. Under the laboratory conditions of our study, we did not find that the TLR2 polymorphism in bank voles influenced variation in the susceptibility to B. afzelii infection. |
| Databáze: | OpenAIRE |
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