The relative effectiveness of fecal immunochemical test-based colorectal cancer screening to detect adenomas and cancer in different demographic and socioeconomic groups. A nationwide cohort study
| Autor: | Mette Bach Larsen, Bo Søborg, Sisse Helle Njor, Thomas Møller Jensen, Peter Ingeholm, Berit Andersen |
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| Rok vydání: | 2022 |
| Předmět: |
Adenoma
Male Cancer Research Epidemiology Public Health Environmental and Occupational Health Adenoma/diagnosis Colonoscopy Colorectal Neoplasms/diagnosis Cohort Studies Socioeconomic Factors Oncology Occult Blood Humans Mass Screening Female Colorectal Neoplasms Early Detection of Cancer Demography Retrospective Studies |
| Zdroj: | Larsen, M B, Søborg, B, Njor, S H, Jensen, T M, Ingeholm, P & Andersen, B 2022, ' The relative effectiveness of fecal immunochemical test-based colorectal cancer screening to detect adenomas and cancer in different demographic and socioeconomic groups : A nationwide cohort study ', European Journal of Cancer Prevention, vol. 31, no. 6, pp. 489-496 . https://doi.org/10.1097/CEJ.0000000000000735 |
| ISSN: | 0959-8278 |
| Popis: | INTRODUCTION: This study aimed at analyzing the relative effectiveness in removal of adenomas and detection of cancer of implementing colorectal cancer (CRC) screening in different demographic and socioeconomic groups.METHODS: This register-based retrospective cohort study included residents aged 50-72 years. Those randomly selected to be invited for CRC screening from 1 March 2014 to 30 June 2015 were classified as invited; those invited from 1 January 2016 to 31 December 2017 were classified as not yet invited. Strata-specific relative risks (RRs) of having adenomas removed and CRC detected were estimated.RESULTS: A total of 1 343 090 individuals were included. The RR of having adenomas removed were higher among men compared with women [RRwomen = 6.41 (95% confidence interval [CI]: 5.08-8.09), RRmen = 7.74 (95% CI: 6.16-9.73), P < 0.01] and among Danes compared with immigrants [RRDanes = 4.71 (95% CI: 3.73-5.93), RRWestern = 4.76 (95% CI: 3.39-6.69), RRnon-Western = 3.35 (95% CI: 2.39-4.69), P = 0.03]. Regarding detection of CRC, the effectiveness increased with increasing age ranging from RR = 1.53 (95% CI: 0.93- 2.51) to RR = 1.97 (95% CI: 1.22-3.17) (P = 0.04) and was higher among men compared with women (RRwomen = 1.75 (95% CI: 1.10-2.76), RRmen = 2.07 (95% CI: 1.32-3.26), P = 0.02.CONCLUSION: Attention must be paid to the potential differences in screening effectiveness among diverse subpopulations; first, by securing equal opportunities for participation across subpopulations and second, by considering sex and age-specific screening programs. |
| Databáze: | OpenAIRE |
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