Streptococcus agalactiae strains isolated from cancer patients in Rio de Janeiro, Brazil
| Autor: | Prescilla Emy Nagao, Ana Luíza Mattos-Guaraldi, Pamella Silva Lannes-Costa, Glenda F. Sanches, Melissa Coimbra Cristoforêto, Kelly S. Doran |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Serotype Adolescent Genotype Virulence Factors Tetracycline Erythromycin Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology Streptococcus agalactiae Young Adult 03 medical and health sciences Bacterial Proteins Drug Resistance Multiple Bacterial Neoplasms Streptococcal Infections Media Technology medicine Humans Pathogen Norfloxacin 030304 developmental biology 0303 health sciences 030306 microbiology Clindamycin Middle Aged Anti-Bacterial Agents Multiple drug resistance Clinical Microbiology - Short Communication Brazil medicine.drug |
| Zdroj: | Braz J Microbiol |
| ISSN: | 1678-4405 1517-8382 |
| Popis: | Streptococcus agalactiae is a recognized pathogen associated with infections in neonates, elderly, and immunocompromised adults, particularly those with cancer. In the present investigation, clinical-epidemiological features, multidrug resistance profiles, and virulence genes of S. agalactiae strains isolated from cancer patients were investigated. S. agalactiae capsular distribution assays demonstrated that Ia (43.6%) and V (23.6%) types were predominantly detected among 55 clinical isolates tested; only one strain (GBS1428) was capsular type III/ST-17. The fbsB and hylB genes were detected in all isolates, while the iag, lmb, and fbsA genes were detected in 94.5%, 91%, and 91% of oncological isolates, respectively. The combination of PI-1 and PI-2a was the most common (60%) among S. agalactiae strains isolated from oncologic patients. S. agalactiae strains were resistant to tetracycline (85.5%), erythromycin (9%), and clindamycin (5.5%). Norfloxacin non-susceptible was detected in 7.3% of S. agalactiae strains. Our findings reinforce the need for S. agalactiae control measures in Brazil, including cancer patients. |
| Databáze: | OpenAIRE |
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