Verbal Episodic Memory Alterations and Hippocampal Atrophy in Acute Mild Traumatic Brain Injury
| Autor: | Olivier Fortier-Lebel, Malo Gaubert, Johannes Frasnelli, Fanny L'Ecuyer-Giguère, Jean-François Giguère, Benjamin Boller, Jean-François Gagnon, Benoît Jobin |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 030506 rehabilitation medicine.medical_specialty Time Factors Future studies Traumatic brain injury Memory Episodic Hippocampus Audiology Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Episodic memory Brain Concussion Memory Disorders medicine.diagnostic_test business.industry Word Recall Neuropsychology Magnetic resonance imaging Organ Size Verbal Learning medicine.disease Magnetic Resonance Imaging Hippocampal atrophy Case-Control Studies Female Neurology (clinical) Atrophy 0305 other medical science business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of Neurotrauma. 38:1506-1514 |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/neu.2020.7475 |
| Popis: | Episodic memory deficit is a symptom frequently observed after a mild traumatic brain injury (mTBI). However, few studies have investigated the impact of a single and acute mTBI on episodic memory and structural cerebral changes. To do so, we conducted two experiments. In the first, we evaluated verbal episodic memory by using a word recall test, in 52 patients with mTBI (mean age 33.1 [12.2] years) 2-4 weeks after a first mTBI, compared with 54 healthy controls (31.3 [9.2] years) and followed both groups up for 6 months. In the second, we measured hippocampal volume in a subset of 40 participants (20 patients with mTBI, 20 controls) from Experiment 1 using magnetic resonance imaging (MRI; T1-weighted images) and correlated memory performance scores to hippocampal volume. Experiment 1 showed significantly reduced verbal episodic memory within the first month after an mTBI and a tendency for a reduction 6 months later, more pronounced for men. In Experiment 2, patients with mTBI exhibited a generally reduced hippocampal volume; however, we did not observe any linear correlation between hippocampal volume and memory scores. These results suggest that one single mTBI is associated with both episodic memory alteration and reduced volume of the hippocampus in the acute phase. Future studies are needed to elucidate the link between both measures. |
| Databáze: | OpenAIRE |
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