ErbB4/HER4: Role in Mammary Gland Development, Differentiation and Growth Inhibition
| Autor: | Karen E. Strunk, Rebecca S. Muraoka-Cook, Shu Mang Feng, Shelton Earp |
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| Rok vydání: | 2008 |
| Předmět: |
Cancer Research
Receptor ErbB-4 animal structures Cellular differentiation Breast Neoplasms Article Receptor tyrosine kinase Mice chemistry.chemical_compound Mammary Glands Animal Biomarkers Tumor Tumor Cells Cultured Animals Humans Protein Isoforms Mammary Glands Human ERBB4 biology Cell Differentiation Cell cycle Growth Inhibitors ErbB Receptors Oncology chemistry biology.protein Cancer research Female Growth inhibition Signal transduction Tyrosine kinase Platelet-derived growth factor receptor Signal Transduction |
| Zdroj: | Journal of Mammary Gland Biology and Neoplasia. 13:235-246 |
| ISSN: | 1573-7039 1083-3021 |
| DOI: | 10.1007/s10911-008-9080-x |
| Popis: | The ErbB receptor tyrosine kinase family has often been associated with increased growth of breast epithelial cells, as well as malignant transformation and progression. In contrast, ErbB4/HER4 exhibits unique attributes from a two step proteolytic cleavage which releases an 80 kilodalton, nuclear localizing, tyrosine kinase to a signal transduction mechanism that slows growth and stimulates differentiation of breast cells. This review provides an overview of ErbB4/HER4 in growth and differentiation of the mammary epithelium, including its physiologic role in development, the contrasting growth inhibition/tumor suppression and growth acceleration of distinct ErbB4/HER4 isoforms and a description of the unique cell cycle regulated pattern of nuclear HER4 ubiquitination and destruction. |
| Databáze: | OpenAIRE |
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