Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older

Autor: Yiming Mu, Kun Zhao, Haibin Wang, Kang Chen, Zhao-hui Lü, Shanshan Yang
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
China
Waist
Article Subject
Cross-sectional study
Endocrinology
Diabetes and Metabolism
030209 endocrinology & metabolism
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Impaired glucose tolerance
Prediabetic State
03 medical and health sciences
0302 clinical medicine
Endocrinology
Asian People
Risk Factors
Diabetes mellitus
Internal medicine
Glucose Intolerance
medicine
Odds Ratio
Prevalence
Humans
030212 general & internal medicine
Prediabetes
Triglycerides
Aged
Glucose tolerance test
lcsh:RC648-665
medicine.diagnostic_test
business.industry
nutritional and metabolic diseases
Odds ratio
Glucose Tolerance Test
Middle Aged
medicine.disease
Impaired fasting glucose
Lipids
Hypertriglyceridemic Waist
Cross-Sectional Studies
Phenotype
Regression Analysis
Female
Waist Circumference
business
Research Article
Zdroj: Journal of Diabetes Research, Vol 2018 (2018)
Journal of Diabetes Research
ISSN: 2314-6753
2314-6745
Popis: Objective. To investigate the association between the hypertriglyceridemic waist (HTGW) phenotype and prediabetes in Chinese adults aged 40 years and older. Methods. 12757 adults (4101 men and 8656 women) without diabetes or cardiovascular and cerebrovascular diseases, free of using lipid-modified agents, were enrolled in this cross-sectional study. The HTGW phenotype was defined as elevated serum triglyceride concentrations and enlarged waist circumference. A two-hour post 75 g oral glucose tolerance test was performed in all participants. Multiple logistic regression analysis was used to evaluate the relationship of the HTGW phenotype with prediabetes. Results. Individuals with the HTGW phenotype had a higher adjusted odds ratio (OR: 1.70; 95% CI: 1.48–1.95) of prediabetes than those without the phenotype. There existed a strong relationship of the HTGW phenotype with impaired glucose tolerance (IGT) (OR: 1.83; 95% CI: 1.57–2.13), but not with impaired fasting glucose (IFG) (OR: 0.87; 95% CI: 0.65–1.17). Only women with the HTGW phenotype are significantly associated with the combined IFG and IGT (OR: 1.83; 95% CI: 1.28–2.62). Conclusions. The HTGW phenotype was a useful risk indicator and a practical screening tool to benefit in the early diagnosis and intervention for prediabetes, particularly for IGT and the combined IFG and IGT.
Databáze: OpenAIRE
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