Memory Modulation by Weak Synchronous Deep Brain Stimulation: A Pilot Study
| Autor: | Bernhard P. Staresina, Nikolai Axmacher, Christoph Helmstaedter, Anne T. A. Do Lam, Guido Widman, Juergen Fell, Christian E. Elger |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Rhinal cortex Deep brain stimulation therapy [Epilepsy Temporal Lobe] Deep Brain Stimulation medicine.medical_treatment Biophysics Hippocampus DBS Stimulation Pilot Projects Electroencephalography Neuropsychological Tests Synchronization Verbal learning Temporal lobe lcsh:RC321-571 Epilepsy medicine methods [Deep Brain Stimulation] Declarative memory Humans ddc:610 therapy [Memory Disorders] lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Memory Disorders Analysis of Variance medicine.diagnostic_test General Neuroscience complications [Epilepsy Temporal Lobe] Middle Aged Verbal Learning medicine.disease Magnetic Resonance Imaging etiology [Memory Disorders] Epilepsy Temporal Lobe Female Neurology (clinical) Psychology Neuroscience |
| Zdroj: | Brain Stimulation, Vol 6, Iss 3, Pp 270-273 (2013) Brain stimulation 6(3), 270-273 (2013). doi:10.1016/j.brs.2012.08.001 |
| DOI: | 10.1016/j.brs.2012.08.001 |
| Popis: | Zero-lag phase synchronization of EEG activity has been reported to be a central mechanism accompanying long-term memory formation. In this pilot study, we examined the effects of synchronous low-amplitude stimulation of the rhinal cortex and the hippocampus in eleven temporal lobe epilepsy patients. The impact of in-phase stimulation (zero lag) on long-term memory encoding of words was contrasted with anti-phase (180° phase lag) and sham stimulation. We hypothesized more correctly remembered words for the in-phase compared to the sham condition and fewer correctly remembered words for the anti-phase vs. the sham condition. Indeed, we observed a trend for a linear condition effect for correctly remembered words, which is in accordance to our prediction (in-phase > sham > anti-phase). This finding suggests that even weak synchronous deep brain stimulation of rhinal cortex and hippocampus may modulate memory performance, while clear evidence for an enhancement of memory by this kind of deep brain simulation is still lacking. |
| Databáze: | OpenAIRE |
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