Are infectious agents involved in the pathogenesis of postpartum psychosis?

Autor: Steven A. Kushner, Lot de Witte, Veerle Bergink, Astrid M. Kamperman, G. Snijders, René S. Kahn, Manja Litjens
Přispěvatelé: Psychiatry
Rok vydání: 2017
Předmět:
Herpesvirus 4
Human
Cytomegalovirus/immunology
Herpesvirus 2
Human
Antibodies
Protozoan
Cytomegalovirus
Herpesvirus 1
Human
Herpesvirus 1
Human/immunology
medicine.disease_cause
Antibodies
Viral
Viral/blood
Immunoglobulin G
Cohort Studies
Antibodies
Viral/blood
0302 clinical medicine
Pregnancy
Seroepidemiologic Studies
Herpesvirus 2
Human/immunology
Prevalence
Medicine
Non-U.S. Gov't
biology
Research Support
Non-U.S. Gov't
Postpartum Period
Human/immunology
Antibody titer
Middle Aged
Psychiatry and Mental health
Clinical Psychology
Female
Postpartum Period/immunology
Antibody
Toxoplasma
Herpesvirus 4
Human/immunology
Adult
Toxoplasma/immunology
Research Support
Antibodies
Puerperal Disorders/epidemiology
Virus
03 medical and health sciences
Immune system
Journal Article
Protozoan/blood
Humans
Antibodies
Protozoan/blood
Herpesvirus 1
business.industry
Herpesvirus 2
Herpesvirus 4
Psychotic Disorders/epidemiology
Puerperal Disorders
Immunoglobulin M/blood
medicine.disease
030227 psychiatry
Herpes simplex virus
Cross-Sectional Studies
Immunoglobulin M
Psychotic Disorders
Immunoglobulin G/blood
Infectious disease (medical specialty)
Immunology
biology.protein
Postpartum psychosis
business
030217 neurology & neurosurgery
Zdroj: Journal of Affective Disorders, 229, 141-144. Elsevier
Journal of Affective Disorders, 229, 141. Elsevier
ISSN: 1573-2517
0165-0327
Popis: Background Since postpartum psychosis has been linked to activation of the immune system, it has been hypothesized that infectious agents may be involved in the pathogenesis of this disorder. We therefore investigated whether exposure to pathogens that can infect the central nervous system is increased in patients with postpartum psychosis. Methods We measured the prevalence and titers of immunoglobulin G (IgG) and M (IgM) to herpes simplex virus type 1 (HSV-1) and 2 (HSV-2), Epstein-Barr virus (EBV), cytomegalovirus (CMV) and Toxoplasma Gondii (TG) in a cohort of patients with postpartum psychosis (n = 81) and compared these to matched postpartum controls. Results We did not find significant differences in seroprevalence or antibody titers for any of these pathogens. Limitations Limitations of this study include the indirect measurement of infectious disease and the cross-sectional design. Conclusion Our results do not support the hypothesis that exposure to these neurotropic pathogens is involved in postpartum psychosis.
Databáze: OpenAIRE
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