Cell growth on electrospun nanofiber mats from polyacrylonitrile (PAN) blends
| Autor: | Andrea Ehrmann, Ines Kutzli, Anke Rattenholl, Al Mamun, Dirk Lütkemeyer, Elise Diestelhorst, Hannah Blattner, Frank Gudermann, Daria Wehlage |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
food.ingredient
Materials science lcsh:Medical technology cho cells lcsh:Biotechnology Gelatin chemistry.chemical_compound food lcsh:TP248.13-248.65 cell growth lcsh:Chemical engineering electrospinning chemistry.chemical_classification nanofiber mat adherent cells Polyacrylonitrile Substrate (chemistry) food and beverages lcsh:TP155-156 Polymer Adhesion Electrospinning dmso chemistry Chemical engineering lcsh:R855-855.5 Nanofiber autoclaving Polymer blend |
| Zdroj: | AIMS Bioengineering, Vol 7, Iss 1, Pp 43-54 (2020) |
| ISSN: | 2375-1495 2375-1487 |
| Popis: | Nanofiber mats can be produced by electrospinning from diverse polymers and polymer blends as well as with embedded ceramics, metals, etc. The large surface-to-volume ratio makes such nanofiber mats a well-suited substrate for tissue engineering and other cell growth experiments. Cell growth, however, is not only influenced by the substrate morphology, but also by the sterilization process applied before the experiment as well as by the chemical composition of the fibers. A former study showed that cell growth and adhesion are supported by polyacrylonitrile/gelatin nanofiber mats, while both factors are strongly reduced on pure polyacrylonitrile (PAN) nanofibers. Here we report on the influence of different PAN blends on cell growth and adhesion. Our study shows that adding ZnO to the PAN spinning solution impedes cell growth, while addition of maltodextrin/pea protein or casein/gelatin supports cell growth and adhesion. |
| Databáze: | OpenAIRE |
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