In arthritis the Doppler based degree of hypervascularisation shows a positive correlation with synovial leukocyte count and distinguishes joints with leukocytes greater and less than 5/nL
| Autor: | Uta Löffler, Michael Uppenkamp, Daniel Wadsack, Horst Sattler, Raoul Bergner, Lena Peters, Christian Löffler, Anika Tuleweit |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male musculoskeletal diseases Pathology medicine.medical_specialty Adolescent Arthritis Inflammation Leukocyte Count Young Adult 03 medical and health sciences chemistry.chemical_compound symbols.namesake 0302 clinical medicine Vascularity Rheumatology Synovial Fluid medicine Humans 030212 general & internal medicine Aged Retrospective Studies Aged 80 and over 030203 arthritis & rheumatology Neovascularization Pathologic medicine.diagnostic_test business.industry Calcium pyrophosphate Ultrasonography Doppler Middle Aged medicine.disease Gout chemistry Erythrocyte sedimentation rate Rheumatoid arthritis symbols Female medicine.symptom business Doppler effect Biomarkers |
| Zdroj: | Joint Bone Spine. 83:517-523 |
| ISSN: | 1297-319X |
| DOI: | 10.1016/j.jbspin.2015.09.007 |
| Popis: | Power Doppler ultrasound is used to assess joint vascularity in acute arthritis. PDUS signals have been correlated with synovial histology and bone deterioration. Little is known about the correlation between power Doppler signals and synovial white blood count. In our study, we analyzed power Doppler signals in inflammatory joint diseases including gout, calcium pyrophosphate deposition disease, rheumatoid arthritis, spondyloarthritis and others and correlated power Doppler signals with synovial white blood count and with serologic markers of inflammation.We retrospectively evaluated 194 patients with arthritis. All patients underwent joint sonography, power Doppler ultrasound, synovial fluid analysis and blood examination of C-reactive protein and erythrocyte sedimentation rate. Correlation analyses (Spearman and Pearson), Chi(2) test, t-tests, a unifactorial ANOVA and regression analyses were applied.Hypervascularisation in power Doppler was most prominent in gout and calcium pyrophosphate deposition disease. Spondyloarthritis and non-inflammatory joint diseases presented with low degrees of hypervascularisation. Mean synovial white blood count did not differ significantly between crystal-related arthritides, rheumatoid arthritis, spondyloarthritis or other inflammatory joint diseases. There was a positive but weak correlation between power Doppler signals and synovial white blood count (P0.001, rs=0.283), erythrocyte sedimentation rate (P0.001, rs=0.387) and C-reactive protein (P0.001, rs=0.373) over all diagnoses. This was especially relevant in rheumatoid arthritis (P0.01, rs=0.479). Power Doppler degrees 0 and 1 were able to predict synovial leukocytes5/nL, degrees 2 and 3 predict leukocytes≥5/nL (P0.001). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect