Comorbid Medical Conditions in Friedreich Ataxia
| Autor: | Christopher M. Gomez, David A. Lynch, Jennifer Farmer, Grace Yoon, Martin B. Delatycki, Cassandra J Strawser, Chad Hoyle, Alicia Brocht, S. H. Subramony, Theresa A. Zesiewicz, Julianna E. Shinnick, Susan Perlman, Katherine D. Mathews, Kimberly Schadt, George Wilmot, Nicholas S. Wilcox, Eppie M. Yiu |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
congenital hereditary and neonatal diseases and abnormalities Pediatrics medicine.medical_specialty Pathology Ataxia Adolescent Population Comorbidity Disease 030204 cardiovascular system & hematology Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Degenerative disease Prevalence medicine Humans Child education education.field_of_study business.industry nutritional and metabolic diseases Inflammatory Bowel Diseases medicine.disease nervous system diseases Friedreich Ataxia Child Preschool Growth Hormone Pediatrics Perinatology and Child Health Cohort Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Natural history study Cohort study |
| Zdroj: | Journal of Child Neurology. 31:1161-1165 |
| ISSN: | 1708-8283 0883-0738 |
| Popis: | Friedreich ataxia is a progressive degenerative disease with neurologic and cardiac involvement. This study characterizes comorbid medical conditions in a large cohort of patients with Friedreich ataxia. Patient diagnoses were collected in a large natural history study of 641 subjects. Prevalence of diagnoses in the cohort with Friedreich ataxia was compared with prevalence in the population without Friedreich ataxia. Ten patients (1.6%) had inflammatory bowel disease, 3.5 times more common in this cohort of individuals with Friedreich ataxia than in the general population. Four subjects were growth hormone deficient, reflecting a prevalence in Friedreich ataxia that is 28 times greater than the general population. The present study identifies specific diagnoses not traditionally associated with Friedreich ataxia that are found at higher frequency in this disease. These associations could represent coincidence, shared genetic background, or potentially interactive disease mechanisms with Friedreich ataxia. |
| Databáze: | OpenAIRE |
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