Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin
| Autor: | Jarogniew J. Luszczki, Marta Halasa, Anna Wawruszak, Daariimaa Khurelbat, Estera Okon, Wirginia Kukula-Koch, Andrzej Stepulak, Agata Jarzab |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
magnoflorine
Aporphines cisplatin isobolographic analysis Antineoplastic Agents Pharmacology Mass Spectrometry Article Catalysis Inorganic Chemistry lcsh:Chemistry chemistry.chemical_compound breast cancer Cell Line Tumor medicine Humans Aporphine Physical and Theoretical Chemistry Lung cancer Rhabdomyosarcoma Menispermaceae Molecular Biology lcsh:QH301-705.5 Chromatography High Pressure Liquid Spectroscopy Cell Proliferation Cisplatin biology Chemistry Alkaloid Organic Chemistry glioblastoma Drug Synergism General Medicine medicine.disease biology.organism_classification Chemotherapy regimen Computer Science Applications lung cancer lcsh:Biology (General) lcsh:QD1-999 Drug Resistance Neoplasm rhabdomyosarcoma Magnoflorine medicine.drug |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 2848, p 2848 (2020) International Journal of Molecular Sciences Volume 21 Issue 8 |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Magnoflorine is an aporphine alkaloid present in plant species belonging to the Berberidaceae, Magnoliaceae, Menispermaceae, or Papaveraceae botanical families. The interest of magnoflorine has increased recently due to its multiplicity of pharmacological properties. The aim of this study was the analysis of combined anti-proliferative effect of magnoflorine and cisplatin and the assessment of drug&ndash drug pharmacological interaction between these agents using isobolographic method in MDA-MB-468 human breast, NCIH1299 lung, TE671 rhabdomyosarcoma, or T98G glioblastoma cancer cell lines. Magnoflorine in combination with cisplatin at a fixed ratio of 1:1 augmented their anticancer action and yielded synergistic or additive pharmacological interactions by means of isobolographic method, therefore combined therapy using these two active agents can be a promising chemotherapy regimen in the treatment of some types of breast, lung, rhabdomyosarcoma, and glioblastoma cancers. |
| Databáze: | OpenAIRE |
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