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This study investigated the cytotoxicity, the residual monomer release, degree of conversion (DC), calcium ion (CaThe cytotoxicity of the cured materials was evaluated on human dental pulp stem cells (hDPSCs) isolated from third molars by the water-soluble tetrazolium salt (WST-1) method. The monomer release and DC of the resin-containing materials were analyzed by high-performance liquid chromatography (HPLC) and Fourier transform infrared (FTIR), respectively. The chemical composition and CaMTA showed significantly lower cytotoxicity than either ThLC or ThPT after 1, 3, and 7 days (p 0.05). TEGDMA release of ThPT is significantly higher than ThLC (p 0.05). All materials showed calcium CaMTA showed low cytotoxicity and high CaThe cytotoxicity and residual monomer release of ThLC and ThPT may raise concerns about the viability of hDPSCs. Further investigations with the use of in vivo research models are required to validate in vitro bioactivity properties and the potential adverse biological effects of ThLC and ThPT on hDPSCs. |
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