The effects of electroacupuncture and laser acupuncture therapy for patients with major trauma: A study protocol
| Autor: | Chun-Ting Liu, Ting-Min Hsieh, Fu-Yuan Shih, Wei-Hung Lai, Ching-Hua Hsieh, Bei-Yu Wu, Yung-Hsiang Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Acupuncture Therapy General Medicine cholinergic anti-inflammatory pathway laser acupuncture major trauma Electroacupuncture Treatment Outcome Study Protocol Clinical Trial inflammation Humans Wounds and Injuries Laser Therapy Prospective Studies Acupuncture Points acupuncture Randomized Controlled Trials as Topic Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Background: Major trauma is the leading cause of death in the young population. The inflammatory and anti-inflammatory responses are associated with posttraumatic morbidity and mortality; however, it is not fully clear how to reestablish the homeostasis in patients with major trauma. Methods: This study will be a prospective, randomized, placebo-controlled, partially double-blinded, three-armed trial. One hundred eighty participants diagnosed with major trauma will be randomly assigned to an electroacupuncture (EA), a laser acupuncture (LA), or a sham laser acupuncture group in a 1:1:1 ratio. All participants will undergo EA, LA, or sham laser acupuncture intervention once a day on 5 acupoints (LI4, PC6, ST36, SP6, and EX-HN1) for 14 consecutive days after enrollment. The primary outcome measure will be the length of hospital stay. Secondary outcomes will be inflammatory mediators, including serum C-reactive protein, interleukin (IL)-6, tumor necrosis factor-α, IL-1β, and IL-10. Clinical outcomes will be numeric rating scale scores for pain, sequential organ failure assessment, ICU length of stay, 30-day mortality, and WHO Disability Assessment Schedule. Data will be analyzed by chi-square test or t test for pairwise comparisons, as well as one-way ANOVA followed by post hoc Tukey method between groups. Objectives: The aim of this protocol is to investigate the clinical effects of EA and LA on major trauma. Trial registration: ClinicalTrials.gov Identifier: NCT04970433. Registered on July 21, 2021. |
| Databáze: | OpenAIRE |
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