Pig Conceptuses Secrete Estrogen and Interferons to Differentially Regulate Uterine STAT1 in a Temporal and Cell Type-Specific Manner
| Autor: | R. Neil Hooper, Robert C. Burghardt, Greg A. Johnson, James R. Burghardt, Margaret M. Joyce, Morgan D. Ashworth, Rodney D. Geisert, Jason W. Ross |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Swine medicine.drug_class medicine.medical_treatment Embryonic Development Endometrium Paracrine signalling Endocrinology Pregnancy Internal medicine medicine Animals Conceptus Embryo Implantation STAT1 Autocrine signalling reproductive and urinary physiology Estradiol biology urogenital system Uterus Blastocyst STAT1 Transcription Factor medicine.anatomical_structure Cytokine Secretory protein Gene Expression Regulation Estrogen embryonic structures biology.protein Female |
| Zdroj: | Endocrinology. 148:4420-4431 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/en.2007-0505 |
| Popis: | Conceptus trophectoderm and uterine luminal epithelial cells interact via endocrine, paracrine, and autocrine modulators to mediate pregnancy recognition and implantation. Pig conceptuses not only release estrogens for pregnancy recognition but also secrete interferons during implantation. Because interferon-stimulated genes are increased by interferons secreted for pregnancy recognition in ruminants, we asked whether the interferon-stimulated gene, STAT1, is up-regulated in pig endometrium by conceptus estrogens and/or interferons. STAT1 expression in response to day of pregnancy, estrogen injection, and intrauterine infusion of conceptus secretory proteins in pigs indicated 1) estrogen increases STAT1 in luminal epithelial cells, 2) conceptus secretory proteins that contain interferons increase STAT1 in stroma, 3) STAT1 increases in close proximity to the conceptus, and 4) early estrogen results in conceptus death and no STAT1 in stroma. The interactions of estrogen and interferons to regulate cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|