Calcium Metabolism Disturbances in Sarcoidosis
| Autor: | Thierry Pepersack, Jacques Bagon, A. Bergans, G. Mandart, Clémentine Gillet, Michel Fuss, Rafik Karmali, Jacques Corvilain |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Sarcoidosis Renal function Normal serum Gastroenterology Calcitriol Internal medicine Biopsy medicine Humans Hypercalciuria Aged Calcium metabolism medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Urinary calcium Endocrinology Hypercalcemia Prednisolone Calcium Female business medicine.drug |
| Zdroj: | Acta Clinica Belgica. 42:421-430 |
| ISSN: | 2295-3337 1784-3286 |
| DOI: | 10.1080/22953337.1987.11719260 |
| Popis: | SummarySarcoidosis was confirmed by biopsy in 13 out of 16 patients in which the disease was suspected. Hypercalcemia was present in 4 patients, associated with renal insufficiency; hypercalciuria without hypercalcemia was found in 3 patients with a normal glomerular filtration rate; 9 patients had normal serum and urinary calcium. Circulating 1, 25-dihydroxyvitamin D (l,25(OH), D) was increased in hypercalcemic patients, in spite of renal insufficiency. Corticosteroid treatment rapidly normalized l,25(OH)2D levels in a few days, and corrected hypercalcemia. In one patient, the progressive reduction of prednisolone to 2.5 mg/day was followed by the recurrence of hypercalcemia. One patient exhibited before corticotheraPy a recurrent seasonal hypercalcemia. The absence of calcium metabolism abnormalities in about 50% of our patients could correspond in some cases to inactive sarcoidosis and/or to a low level of 25-hydroxyvitamin D, the precursor of l,25(OH)2D, but remained without explanation in other patie... |
| Databáze: | OpenAIRE |
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