Statistical methods for constructing disease comorbidity networks from longitudinal inpatient data
| Autor: | David L. Buckeridge, Babak Fotouhi, Naghmeh Momeni, Maria A. Riolo |
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| Přispěvatelé: | Sloan School of Management, Momeni Taramsari, Naghmeh |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Computer Networks and Communications Computer science Weighted networks Network science Disease Comorbidity 03 medical and health sciences Disease networks Hospital discharge medicine Centrality Structure (mathematical logic) Multidisciplinary Null model Research lcsh:T57-57.97 medicine.disease Data science Computational Mathematics 030104 developmental biology Null (SQL) lcsh:Applied mathematics. Quantitative methods |
| Zdroj: | Applied Network Science, Vol 3, Iss 1, Pp 1-34 (2018) Springer International Publishing Applied Network Science |
| ISSN: | 2364-8228 |
| Popis: | Tools from network science can be utilized to study relations between diseases. Different studies focus on different types of inter-disease linkages. One of them is the comorbidity patterns derived from large-scale longitudinal data of hospital discharge records. Researchers seek to describe comorbidity relations as a network to characterize pathways of disease progressions and to predict future risks. The first step in such studies is the construction of the network itself, which subsequent analyses rest upon. There are different ways to build such a network. In this paper, we provide an overview of several existing statistical approaches in network science applicable to weighted directed networks. We discuss the differences between the null models that these models assume and their applications. We apply these methods to the inpatient data of approximately one million people, spanning approximately 17 years, pertaining to the Montreal Census Metropolitan Area. We discuss the differences in the structure of the networks built by different methods, and different features of the comorbidity relations that they extract. We also present several example applications of these methods. Keywords: Weighted networks; Null model; Comorbidity; Disease networks; Centrality |
| Databáze: | OpenAIRE |
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