Gene-targeting approaches in the study of cellular processes involved in growth or differentiation. Advances in the analysis of oncogenes, tumour-suppressor genes, cytokine/receptor systems and developmental control genes
| Autor: | Kazuhisa Sugimura, Gen Yamada, Edward T. Stuart |
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| Rok vydání: | 1994 |
| Předmět: |
Stem Cells
Mutant Gene targeting Cell Differentiation Oncogenes Biology Embryo Mammalian Biochemistry Embryonic stem cell Genome Cell biology Genes Gene Targeting Homeobox Animals Cytokines Humans Genes Tumor Suppressor Receptors Cytokine Homologous recombination Cytokine receptor Gene Cell Division |
| Zdroj: | European journal of biochemistry. 226(3) |
| ISSN: | 0014-2956 |
| Popis: | Recent advances in embryonic stem cell (ES) technology have made it possible to introduce mutations into the mouse genome by homologous recombination and thereby selectively generate mutant mice. Genetically manipulated mutant mice have contributed enormously to our understanding of the molecular functions of isolated genes and the mechanisms of cell growth and differentiation, as well as increasing our understanding of diseases such as cancer. Here, we will briefly summarise the recent advances in gene-targeting studies with particular emphasis on growth factors and their receptors, oncogenes, tumour-suppressor genes and developmental control genes. |
| Databáze: | OpenAIRE |
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