The predictive value of cumulative lactate dehydrogenase release within the first 72 h of acute myocardial infarction in patients treated with primary angioplasty

Autor: Robbert J. Slingerland, Peter Elsman, Felix Zijlstra, Harry Suryapranata, Menko-Jan de Boer, Kor Miedema, Lambert D Dikkeschei, Jan C.A. Hoorntje, Stoffer Reiffers
Přispěvatelé: Faculteit Medische Wetenschappen/UMCG
Rok vydání: 2004
Předmět:
Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
ALPHA-HYDROXYBUTYRATE DEHYDROGENASE
Clinical Biochemistry
Myocardial Infarction
Infarction
Tissue plasminogen activator
chemistry.chemical_compound
LEFT-VENTRICULAR FUNCTION
Predictive Value of Tests
Risk Factors
Lactate dehydrogenase
Internal medicine
medicine
Humans
In patient
cardiovascular diseases
Myocardial infarction
Angioplasty
Balloon
Coronary
Aged
Ejection fraction
L-Lactate Dehydrogenase
biology
business.industry
CREATINE-KINASE
Percutaneous coronary intervention
General Medicine
Middle Aged
medicine.disease
INTRAVENOUS STREPTOKINASE
TISSUE PLASMINOGEN-ACTIVATOR
LONG-TERM BENEFIT
CORONARY-ARTERY REPERFUSION
THROMBOLYTIC THERAPY
SIZE
chemistry
cardiovascular system
Cardiology
biology.protein
TRIAL
Female
Creatine kinase
business
Biomarkers
medicine.drug
Zdroj: Annals of Clinical Biochemistry, 41, 142-148. SAGE Publications Inc.
ISSN: 1758-1001
0004-5632
DOI: 10.1258/000456304322880041
Popis: Background: In patients with acute myocardial infarction, estimation of infarct size by cumulative lactate dehydrogenase release at 72 h (LDHQ72) is a simple and widely used method. Our objective was to study the value of estimating infarct size, by the cumulative release of LDH over 72, 60, 48 and 36 h in predicting left ventricular ejection fraction (LVef) and cardiac death at 1 year. Methods: In the Zwolle Infarction Study infarct size estimated as LDHQ was calculated in 1224 patients treated with primary percutaneous coronary intervention for acute myocardial infarction between December 1993 and June 2001. Patients were categorized as having small (LDHQ7272 800-2500 U/L) or large (LDHQ72>2500 U/L) myocardial infarction. Results: LDHQ72 was closely correlated with LDHQ60, LDHQ48 and LDHQ36 ( r = 0.998, 0.993 and 0.987, respectively, P ef (51% vs 45% vs 35%, P Conclusion: Infarct size classification based on LDHQ36 is an objective and widely available method for early risk stratification in patients treated with primary angioplasty for acute ST-segment elevation myocardial infarction.
Databáze: OpenAIRE
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