Genomics of body fat percentage may contribute to sex bias in anorexia nervosa
Autor: | Mariaelisa Graff, Julius S. Ngwa, Paul F. O'Reilly, Christopher Hübel, Tsegaselassie Workalemahu, Jonathan R. I. Coleman, Kirstin L. Purves, Cynthia M. Bulik, Gerome Breen, Hilary K. Finucane, Inga Prokopenko, Helena Gaspar, Ken B. Hanscombe, Magic Investigators |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Male Anorexia Nervosa LOCI Physiology Genome-wide association study Body fat percentage Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium Body Mass Index shared genetics 0302 clinical medicine Databases Genetic Eating Disorders Working Group of the Psychiatric Genomics Consortium WIDE ASSOCIATION GWAS Genetics (clinical) Research Articles Genetics & Heredity Psychiatry Schizophrenia Working Group of the Psychiatric Genomics Consortium HERITABILITY Genomics Middle Aged genetic correlation MAGIC investigators 3. Good health fat-free mass Psychiatry and Mental health female Phenotype Adipose Tissue Anorexia nervosa (differential diagnoses) eating disorder Body Composition Life Sciences & Biomedicine Sex ratio Research Article Adult fat‐free mass GENETIC-BASIS Biology Genetic correlation POOLED ANALYSIS 03 medical and health sciences Cellular and Molecular Neuroscience MASS INDEX Sex Factors RISK-FACTOR GLYCEMIC TRAITS Humans Genetic Predisposition to Disease METAANALYSIS 0604 Genetics Science & Technology 1103 Clinical Sciences Anthropometry Heritability 030104 developmental biology BIOLOGICAL INSIGHTS Case-Control Studies Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium 1109 Neurosciences 030217 neurology & neurosurgery Genome-Wide Association Study |
Zdroj: | American Journal of Medical Genetics Hübel, C, Gaspar, H A, Coleman, J R I, Finucane, H, Purves, K L, Hanscombe, K B, Prokopenko, I, Graff, M, Ngwa, J S, Workalemahu, T, O'Reilly, P F, Bulik, C M, Breen, G, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium, MAGIC Investigators & Eating Disorders Working Group of the Psychiatric Genomics Consortium 2019, ' Genomics of body fat percentage may contribute to sex bias in anorexia nervosa ', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 180, no. 6, pp. 428-438 . https://doi.org/10.1002/ajmg.b.32709 Hübel, C, Gaspar, H A, Coleman, J R I, Finucane, H, Purves, K L, Hanscombe, K B, Prokopenko, I, Graff, M, Workalemahu, T, Ngwa, J S & O'Reilly, P F & Bulik, C M & Breen, G 2019, ' Genomics of body fat percentage may contribute to sex bias in anorexia nervosa ', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 180, no. 6, pp. 428-438 . https://doi.org/10.1002/ajmg.b.32709 |
ISSN: | 1552-485X 1552-4841 |
Popis: | Anorexia nervosa (AN) occurs nine times more often in females than in males. Although environmental factors likely play a role, the reasons for this imbalanced sex ratio remain unresolved. AN displays high genetic correlations with anthropometric and metabolic traits. Given sex differences in body composition, we investigated the possible metabolic underpinnings of female propensity for AN. We conducted sex-specific GWAS in a healthy and medication-free subsample of the UK Biobank (n = 155,961), identifying 77 genome-wide significant loci associated with body fat percentage (BF%) and 174 with fat-free mass (FFM). Partitioned heritability analysis showed an enrichment for central nervous tissue-associated genes for BF%, which was more prominent in females than males. Genetic correlations of BF% and FFM with the largest GWAS of AN by the Psychiatric Genomics Consortium were estimated to explore shared genomics. The genetic correlations of BF%male and BF%female with AN differed significantly from each other (p |
Databáze: | OpenAIRE |
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