Genomics of body fat percentage may contribute to sex bias in anorexia nervosa

Autor: Mariaelisa Graff, Julius S. Ngwa, Paul F. O'Reilly, Christopher Hübel, Tsegaselassie Workalemahu, Jonathan R. I. Coleman, Kirstin L. Purves, Cynthia M. Bulik, Gerome Breen, Hilary K. Finucane, Inga Prokopenko, Helena Gaspar, Ken B. Hanscombe, Magic Investigators
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Anorexia Nervosa
LOCI
Physiology
Genome-wide association study
Body fat percentage
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Body Mass Index
shared genetics
0302 clinical medicine
Databases
Genetic
Eating Disorders Working Group of the Psychiatric Genomics Consortium
WIDE ASSOCIATION
GWAS
Genetics (clinical)
Research Articles
Genetics & Heredity
Psychiatry
Schizophrenia Working Group of the Psychiatric Genomics Consortium
HERITABILITY
Genomics
Middle Aged
genetic correlation
MAGIC investigators
3. Good health
fat-free mass
Psychiatry and Mental health
female
Phenotype
Adipose Tissue
Anorexia nervosa (differential diagnoses)
eating disorder
Body Composition
Life Sciences & Biomedicine
Sex ratio
Research Article
Adult
fat‐free mass
GENETIC-BASIS
Biology
Genetic correlation
POOLED ANALYSIS
03 medical and health sciences
Cellular and Molecular Neuroscience
MASS INDEX
Sex Factors
RISK-FACTOR
GLYCEMIC TRAITS
Humans
Genetic Predisposition to Disease
METAANALYSIS
0604 Genetics
Science & Technology
1103 Clinical Sciences
Anthropometry
Heritability
030104 developmental biology
BIOLOGICAL INSIGHTS
Case-Control Studies
Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium
1109 Neurosciences
030217 neurology & neurosurgery
Genome-Wide Association Study
Zdroj: American Journal of Medical Genetics
Hübel, C, Gaspar, H A, Coleman, J R I, Finucane, H, Purves, K L, Hanscombe, K B, Prokopenko, I, Graff, M, Ngwa, J S, Workalemahu, T, O'Reilly, P F, Bulik, C M, Breen, G, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium, MAGIC Investigators & Eating Disorders Working Group of the Psychiatric Genomics Consortium 2019, ' Genomics of body fat percentage may contribute to sex bias in anorexia nervosa ', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 180, no. 6, pp. 428-438 . https://doi.org/10.1002/ajmg.b.32709
Hübel, C, Gaspar, H A, Coleman, J R I, Finucane, H, Purves, K L, Hanscombe, K B, Prokopenko, I, Graff, M, Workalemahu, T, Ngwa, J S & O'Reilly, P F & Bulik, C M & Breen, G 2019, ' Genomics of body fat percentage may contribute to sex bias in anorexia nervosa ', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 180, no. 6, pp. 428-438 . https://doi.org/10.1002/ajmg.b.32709
ISSN: 1552-485X
1552-4841
Popis: Anorexia nervosa (AN) occurs nine times more often in females than in males. Although environmental factors likely play a role, the reasons for this imbalanced sex ratio remain unresolved. AN displays high genetic correlations with anthropometric and metabolic traits. Given sex differences in body composition, we investigated the possible metabolic underpinnings of female propensity for AN. We conducted sex-specific GWAS in a healthy and medication-free subsample of the UK Biobank (n = 155,961), identifying 77 genome-wide significant loci associated with body fat percentage (BF%) and 174 with fat-free mass (FFM). Partitioned heritability analysis showed an enrichment for central nervous tissue-associated genes for BF%, which was more prominent in females than males. Genetic correlations of BF% and FFM with the largest GWAS of AN by the Psychiatric Genomics Consortium were estimated to explore shared genomics. The genetic correlations of BF%male and BF%female with AN differed significantly from each other (p
Databáze: OpenAIRE
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