Hedgehog signaling regulates segment formation in the annelid Platynereis
| Autor: | Aurélien Guillou, Detlev Arendt, Julien Béhague, Kristin Tessmar-Raible, Heidi Snyman, Laura Vibert, Foteini Christodoulou, Martine Le Gouar, Katharina Schipany, Juliane Zantke, Michel Vervoort, Nicolas Dray, Guillaume Balavoine |
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| Přispěvatelé: | Centre de génétique moléculaire (CGM), Centre National de la Recherche Scientifique (CNRS), European Molecular Biology Laboratory, EMBO, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), European Molecular Biology Laboratory [Heidelberg] (EMBL) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
MESH: Signal Transduction
MESH: Piperazines MESH: Veratrum Alkaloids MESH: Amino Acid Sequence Piperazines 0302 clinical medicine MESH: Arthropods MESH: Gene Expression Regulation Developmental MESH: Animals MESH: Phylogeny [SDV.BDD]Life Sciences [q-bio]/Development Biology Phylogeny MESH: Receptors Cell Surface 0303 health sciences Multidisciplinary biology Metamorphosis Biological Veratrum Alkaloids Gene Expression Regulation Developmental Anatomy MESH: Transcription Factors Biological Evolution Hedgehog signaling pathway Cell biology Larva embryonic structures Platynereis Signal Transduction MESH: Body Patterning Patched Patched Receptors animal structures Molecular Sequence Data MESH: Polychaeta Receptors Cell Surface Article 03 medical and health sciences MESH: Gene Expression Profiling MESH: Evolution Animals Hedgehog Proteins Amino Acid Sequence MESH: Metamorphosis Biological Transcription factor Hedgehog Arthropods 030304 developmental biology Body Patterning Annelid MESH: Molecular Sequence Data Gene Expression Profiling Polychaeta MESH: Hedgehog Proteins biology.organism_classification Pyrazoles Arthropod MESH: Larva 030217 neurology & neurosurgery MESH: Pyrazoles Transcription Factors |
| Zdroj: | Science Science, American Association for the Advancement of Science, 2010, 329 (5989), pp.339-42. ⟨10.1126/science.1188913⟩ |
| ISSN: | 0036-8075 1095-9203 |
| DOI: | 10.1126/science.1188913⟩ |
| Popis: | Hedgehog and Segmentation Segmentation is a key characteristic of body plan organization in some of the largest animal groups, including annelids, arthropods, and vertebrates, but its evolutionary origins remain debated. In arthropod embryos, the Hedgehog signaling pathway plays a crucial role in the axial patterning of developing segments. Dray et al. (p. 339 ) analyzed the function of this conserved pathway in the annelid worm Platynereis by using specific small molecule inhibitors and found a similar role for Hedgehog signaling in shaping segments in this animal. Thus, Hedgehog was involved in segment formation in the last common ancestor of the protostome animals, earlier in metazoan evolution than previously assumed. |
| Databáze: | OpenAIRE |
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