The uncertainty of the surgical margin in the treatment of head and neck cancer
| Autor: | Adam Searle, Tahwinder Upile, Colin Hopper, Peter Rhys-Evans, A. Wright, Leslie Michaels, David J. Howard, Cyril Fisher, Waseem Jerjes, D. J. Archer, M. El Maaytah |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Cancer Research
medicine.medical_specialty Surgical margin Neoplasm Residual medicine.medical_treatment Malignancy Margin (machine learning) Adjuvant therapy Humans Medicine Transoral laser microsurgery Neoplasm Metastasis business.industry Head and neck cancer Uncertainty Perioperative medicine.disease Surgery Radiation therapy Oncology Head and Neck Neoplasms Surgical Procedures Operative Radiotherapy Adjuvant Neoplasm Recurrence Local Oral Surgery business |
| Zdroj: | Oral Oncology. 43:321-326 |
| ISSN: | 1368-8375 |
| DOI: | 10.1016/j.oraloncology.2006.08.002 |
| Popis: | We discuss our surgical philosophy concerning the subtle interplay between the size of the surgical margin taken and the resultant morbidity from ablative oncological procedures, which is ever more evident in the treatment of head and neck malignancy. The extent of tissue resection is determined by the "trade off" between cancer control and the perioperative, functional and aesthetic morbidity and mortality of the surgery. We also discuss our dilemmas concerning recent minimally invasive endoscopic microsurgical techniques for the trans-oral laser removal or co-ablation of aero-digestive tract tumours, which result in a minimal surgical margin of oncological clearance. By a process of inductive argument as to the nature of the surgical margin, we consider whether the risks of taking a lesser margin with adjuvant therapy is justified by the attendant gain in reduced surgical morbidity and the possible costs in tumour control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect