Histological evaluation of skin lesions induced by Leishmania braziliensis treated by PACT using Laser light and 1.9 dimethyl-methylene blue

Autor:	Sandra R.C.A. Fagnani, Susana C.P.S. de Oliveira, Juliana S.C. Monteiro, Fernando José Pires Sampaio, Pedro J.L. Crugeira, Jean N. dos Santos, Antonio L.B. Pinheiro
Rok vydání:	2022
Předmět:	Inflammation Methylene Blue Mice Photosensitizing Agents Oncology Photochemotherapy Lasers Biophysics Animals Pharmacology (medical) Dermatology Leishmania braziliensis
Zdroj:	Photodiagnosis and photodynamic therapy. 38
ISSN:	1873-1597
Popis:	This study aimed to perform a histological evaluation in skin lesions caused by Leishmania braziliensis after PACT treatment using Laser associated with 1.9. dimethyl methylene blue BALB/c mouse ear infection model was used. A total of 40 animals were assigned into two groups considering time intervals at 5 and 10 weeks and subdivided into four subgroups: Control, Photosensitizer, Laser and PACT. Two therapeutic interventions were performed after the 5th week of infection at 48 h intervals. 1.9 Dimethyl methylene blue was used as a photosensitizer at the concentration of 7 ng/mL, with a non-invasive topical administration method associated with Laser (λ = 660 nm, 40 mW, 12 J/cm
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a93689ba53ba65e59171af1b57376ce https://pubmed.ncbi.nlm.nih.gov/35306211 Zobrazit plný text záznamu Full Text from ScienceDirect