Matrix Assisted Rapid Evaporative Ionization Mass Spectrometry

Autor:	Emrys A. Jones, Julia Balog, Steven Derek Pringle, Tamás Karancsi, Daniel Simon, Zoltan Takats
Rok vydání:	2019
Předmět:	Time Factors Chromatography Chemistry 010401 analytical chemistry 010402 general chemistry 01 natural sciences Mass Spectrometry 0104 chemical sciences Analytical Chemistry Matrix (chemical analysis) Solvents Sample preparation Volatilization Ionization mass spectrometry
Zdroj:	Analytical Chemistry. 91:9784-9791
ISSN:	1520-6882 0003-2700
Popis:	Rapid evaporative ionization mass spectrometry (REIMS) is a highly versatile technique allowing the sampling of a range of biological solid or liquid samples with no sample preparation. The cost of such a direct approach is that certain sample types provide only moderate amounts of chemical information. Here, we introduce a matrix assisted version of the technique (MA-REIMS), where an aerosol of a pure solvent, such as isopropanol, is mixed with the sample aerosol generated by rapid evaporation of the sample, and it is shown to enhance the signal intensity obtained from a REIMS sampling event by over 2 orders of magnitude. Such an increase greatly expands the scope of the technique, while providing additional benefits such as reducing the fouling of the REIMS source and allowing for a simple method of constant introduction of a calibration correction compound for accurate mass measurements. A range of experiments are presented in order to investigate the processes that occur within this modified approach, and applications where such enhancements are critical, such as intrasurgical tissue identification, are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a933cf9e9ece6351a5a8cb3a50149c8 https://doi.org/10.1021/acs.analchem.9b01441 Zobrazit plný text záznamu