Population genetic data for 21 autosomal STR loci in the Azerbaijani population using the Globalfiler™ kit
| Autor: | Victoria Gellatly, Asmer Aliyeva, Arati Iyengar, Mehraj Abbasov |
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| Rok vydání: | 2021 |
| Předmět: |
Linkage disequilibrium
Azerbaijan Population Biology 01 natural sciences Pathology and Forensic Medicine Loss of heterozygosity 03 medical and health sciences 0302 clinical medicine Gene Frequency Polymorphism (computer science) Population Database Humans 030216 legal & forensic medicine education Allele frequency education.field_of_study 010401 analytical chemistry Hardy–Weinberg principle DNA Fingerprinting 0104 chemical sciences Genetics Population Evolutionary biology Genetic Loci Str loci Microsatellite Repeats |
| Zdroj: | International journal of legal medicine. 135(5) |
| ISSN: | 1437-1596 |
| Popis: | The Republic of Azerbaijan is located in the southern Caucasus mountains, a region which is linguistically and ethnically diverse. We report allele frequency data for 21 autosomal loci from the Globalfiler™ kit in the Azerbaijani population using 467 individuals from Baku. Exact tests for Hardy Weinberg Equilibrium and Linkage Equilibrium were conducted, and all forensic parameters were estimated. High levels of Expected Heterozygosity HE were seen, with a minimum of 0.637 for TPOX and a maximum of 0.949 for SE33. Polymorphism Information Content (PIC) values for all STR loci were high, ranging from 0.587 for TPOX to 0.947 for SE33. Matching probability (MP) estimates ranged from 0.006 for SE33 to 0.178 for TPOX. Power of Discrimination (PD) values for most of the tested loci (17/21) were ≥ 0.9. The Combined Matching Probability (CMP) and the Combined Power of Discrimination (CPD) for all 21 loci were 7.84 × 10–27 and 1.0 respectively. Exact tests for population differentiation using all available Globalfiler™ datasets from across Europe and Asia reveal a general trend of higher differentiation with increasing geographical separation, but there is a need for additional population data from neighboring regions of Azerbaijan. |
| Databáze: | OpenAIRE |
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