High incidence of intact or fragmented immunoglobulin in urine of patients with multiple myeloma
| Autor: | Maria Kraj, Barbara Kruk, Ewa Lech-Marańda, Monika Prochorec-Sobieszek, Krzysztof Warzocha |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Cancer Research Immunoglobulins Urine Kidney Function Tests Immunoglobulin light chain hemic and lymphatic diseases medicine Humans Immunoglobulin Fragments Multiple myeloma Aged Neoplasm Staging Aged 80 and over biology medicine.diagnostic_test business.industry Incidence Hematology Middle Aged medicine.disease Survival Analysis Bence Jones protein Immunoglobulin Isotypes Proteinuria Oncology Immunoassay Immunology biology.protein Female Immunoglobulin Light Chains High incidence Antibody Multiple Myeloma business Nephelometry Follow-Up Studies |
| Zdroj: | Leukemia & Lymphoma. 56:3348-3356 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428194.2015.1037753 |
| Popis: | In this prospective study we determined the incidence of intact/fragmented immunoglobulin and Bence Jones protein in urine immunofixation using Sebia reagents and HydrasysTM 2 apparatus and compared the results to concentrations of serum free light chains (FLC) assessed using Siemens BNTM II nephelometer and the immunoassay Freelite (Binding Site) in 289 patients with multiple myeloma at diagnosis. It was found that in one third of IgG, IgA and IgD myeloma patients, intact/fragmented immunoglobulin can be detected in urine and is connected with impaired renal function and reduced survival. Urine immunofixation detects monoclonal protein (FLC and intact/fragmented immunoglobulin) in 66-79% of IgG and IgA myeloma patients while serum FLC immunoassay detect it in 82-94% of IgG and IgA myeloma patients. However, the latter method is inadequate for detection of intact/fragmented immunoglobulin in urine. Serum FLC immunoassay and urine immunofixation are complementary methods in diagnosing and monitoring monoclonal protein in patients with myeloma. |
| Databáze: | OpenAIRE |
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