Null Cell Adenoma of the Pituitary: Pseudo-rosettes Say It Best When Immunohistochemistry Says Nothing At All!
| Autor: | Pravin Salunke, Kirti Gupta, Sivashanmugam Dhandapani, Vikram Singh |
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| Rok vydání: | 2018 |
| Předmět: |
Sine qua non Radiology-Pathology
Adenoma 0301 basic medicine Ependymoma Steroidogenic factor 1 Pathology medicine.medical_specialty Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine medicine Humans Pituitary Neoplasms Germinoma business.industry Pituitary tumors Histology Middle Aged medicine.disease Immunohistochemistry 030104 developmental biology Oncology Otorhinolaryngology 030220 oncology & carcinogenesis Pituitary null cell adenoma Female Differential diagnosis business |
| Zdroj: | Head and Neck Pathology. 13:677-680 |
| ISSN: | 1936-0568 |
| DOI: | 10.1007/s12105-018-0972-9 |
| Popis: | Null cell adenoma is composed of adenohypophyseal cells that show no evidence of any specific cell type differentiation by immunohistochemistry or transcription factors like pituitary-specific positive transcription factor 1 and steroidogenic factor 1. Though rare, pituitary ependymoma and germinoma are also known to occur at sellar region and in such instances, it is challenging to differentiate them from a pituitary null cell adenoma featuring papillary architecture and perivascular pseudo-rosettes. We describe a case of an elderly diabetic lady presenting with headache and blurring of vision for past 3 months due to a sellar tumour. The histology was diagnostically challenging with notable presence of numerous perivascular pseudo-rosettes and negative immunoreactivity for all pituitary hormones. The differential diagnosis and importance of ancillary techniques is discussed. |
| Databáze: | OpenAIRE |
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