Vitamin D deficiency exacerbates UV/endorphin and opioid addiction
| Autor: | Vanita Chopra, William Sarnie, Weihua Ding, Lajos Kemény, Maryam M. Asgari, Yik Weng Yew, Nicholas Theodosakis, Andrea L. Hermann, Sarah E. Wakeman, Yong-Hwee Eddie Loh, Mack Y. Su, Eric J. Nestler, Deena M. Walker, Jennifer A. Lo, Shinichiro Kato, Phillip D. Rivera, Kathleen C. Robinson, Anita A. J. van der Sande, Susan Regan, Tobias A. Beyer, Matthew P. Salomon, Joseph Kotler, Staci D. Bilbo, Yi Chun Lai, David E. Fisher, Dave S.B. Hoon, Shiqian Shen, Jennifer J. Hsiao, David Kotler, Liuyue Yang |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
vitamin D deficiency Mice 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine Vitamin D and neurology Animals Humans Health and Medicine Vitamin D Opioid addiction Research Articles 030304 developmental biology Endogenous opioid 0303 health sciences Opioid epidemic Multidisciplinary business.industry Opioid use SciAdv r-articles Life Sciences Opioid use disorder Vitamins Opioid-Related Disorders Vitamin D Deficiency medicine.disease Analgesics Opioid Endocrinology Opioid Endorphins business 030217 neurology & neurosurgery Research Article medicine.drug |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.abe4577 |
| Popis: | Addiction to UV light and opioids is increased by VitD deficiency, suggesting that a feedback loop promotes its synthesis. The current opioid epidemic warrants a better understanding of genetic and environmental factors that contribute to opioid addiction. Here we report an increased prevalence of vitamin D (VitD) deficiency in patients diagnosed with opioid use disorder and an inverse and dose-dependent association of VitD levels with self-reported opioid use. We used multiple pharmacologic approaches and genetic mouse models and found that deficiencies in VitD signaling amplify exogenous opioid responses that are normalized upon restoration of VitD signaling. Similarly, physiologic endogenous opioid analgesia and reward responses triggered by ultraviolet (UV) radiation are repressed by VitD signaling, suggesting that a feedback loop exists whereby VitD deficiency produces increased UV/endorphin-seeking behavior until VitD levels are restored by cutaneous VitD synthesis. This feedback may carry the evolutionary advantage of maximizing VitD synthesis. However, unlike UV exposure, exogenous opioid use is not followed by VitD synthesis (and its opioid suppressive effects), contributing to maladaptive addictive behavior. |
| Databáze: | OpenAIRE |
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