Peri-coronary adipose tissue density is associated with 18F-sodium fluoride coronary uptake in stable patients with high-risk plaques
| Autor: | Balaji Tamarappoo, John D. Friedman, Damini Dey, Sebastien Cadet, Mhairi K. Doris, Marc R. Dweck, Maurits A. Jansen, Evann Eisenberg, Hyuk Jae Chang, Daniel S. Berman, Mijin Yun, Michelle C. Williams, Jacek Kwiecinski, David E. Newby, Phi T. Huynh, Piotr J. Slomka, Yuka Otaki, Sang Eun Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Peri Adipose tissue 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Interquartile range Internal medicine Sodium fluoride medicine Radiology Nuclear Medicine and imaging PET-CT medicine.diagnostic_test business.industry medicine.disease body regions chemistry Positron emission tomography Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business Calcification |
| Zdroj: | Kwiecinski, J, Dey, D, Cadet, S, Lee, S-E, Otaki, Y, Huynh, P T, Doris, M, Eisenberg, E, Yun, M, Jansen, M A, Williams, M C, Tamarappoo, B K, Friedman, J D, Dweck, M R, Newby, D E, Chang, H-J, Slomka, P J & Berman, D S 2019, ' Peri-coronary adipose tissue density is associated with 18F-sodium fluoride coronary uptake in stable patients with high-risk plaques. ', JACC: Cardiovascular Imaging, vol. 12, no. 10, pp. 2000-2010 . https://doi.org/10.1016/j.jcmg.2018.11.032 |
| DOI: | 10.1016/j.jcmg.2018.11.032 |
| Popis: | Objectives This study aimed to assess the association between increased lesion peri-coronary adipose tissue (PCAT) density and coronary 18F-sodium fluoride (18F-NaF) uptake on positron emission tomography (PET) in stable patients with high-risk coronary plaques (HRPs) shown on coronary computed tomography angiography (CTA). Background Coronary 18F-NaF uptake reflects the rate of calcification of coronary atherosclerotic plaque. Increased PCAT density is associated with vascular inflammation. Currently, the relationship between increased PCAT density and 18F-NaF uptake in stable patients with HRPs on coronary CTA has not been characterized. Methods Patients who underwent coronary CTA were screened for HRP, which was defined by 3 concurrent plaque features: positive remodeling; low attenuation plaque (LAP) (100 mm3). Patients with HRPs were recruited to undergo 18F-NaF PET/CT. In lesions with stenosis ≥25%, quantitative plaque analysis, mean PCAT density, maximal coronary motion−corrected 18F-NaF standard uptake values (SUVmax), and target-to-background ratios (TBR) were measured. Results Forty-one patients (age 65 ± 6 years; 68% men) were recruited. Fifty-one lesions in 23 patients (56%) showed increased coronary 18F-NaF activity. Lesions with 18F-NaF uptake had higher surrounding PCAT density than those without 18F-NaF uptake (−73 HU; interquartile range −79 to −68 HU vs. −86 HU; interquartile range −94 to −80 HU; p < 0.001). 18F-NaF TBR and SUVmax were correlated with PCAT density (r = 0.63 and r = 0.68, respectively; all p < 0.001). On adjusted multiple regression analysis, increased lesion PCAT density and LAP volume were associated with 18F-NaF TBR (β = 0.25; 95% confidence interval: 0.17 to 0.34; p < 0.001 for PCAT, and β = 0.07; 95% confidence interval: 0.03 to 0.11; p = 0.002 for LAP). Conclusions In patients with HRP features on coronary CTA, increased density of PCAT was associated with focal 18F-NaF PET uptake. Simultaneous assessment of these imaging biomarkers by 18F-NaF PET and CTA might refine cardiovascular risk prediction in stable patients with HRP features. |
| Databáze: | OpenAIRE |
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