Prevalence of increased canine pancreas‐specific lipase concentrations in young dogs with parvovirus enteritis
| Autor: | Irida V Kalli, Katerina K. Adamama-Moraitou, Timoleon S Rallis, Michael N Patsika, George Menexes, Jörg M. Steiner, Jan S. Suchodolski, Georgia Brellou, Dimitra Pardali |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Pathology 040301 veterinary sciences Gastroenterology Group A Group B Enteritis Parvoviridae Infections Parvovirus 0403 veterinary science 03 medical and health sciences Dogs 0302 clinical medicine Blood serum Internal medicine Prevalence medicine Animals Dog Diseases Prospective Studies General Veterinary biology business.industry Canine parvovirus Lipase 04 agricultural and veterinary sciences medicine.disease biology.organism_classification Systemic Inflammatory Response Syndrome Pancreatitis Acute pancreatitis Female 030211 gastroenterology & hepatology business |
| Zdroj: | Veterinary Clinical Pathology. 46:111-119 |
| ISSN: | 1939-165X 0275-6382 |
| DOI: | 10.1111/vcp.12447 |
| Popis: | Background Pancreatic abnormalities during canine parvovirus (CPV) enteritis have not been studied prospectively. Objectives The objective of this study was to evaluate the diagnostic significance of canine serum pancreas-specific lipase (Spec cPL) concentration in dogs with CPV enteritis for the presence of acute pancreatitis (AP). Puppies with naturally occurring CPV enteritis were recruited and prospectively allocated into 2 groups according to normal or increased serum Spec cPL concentration. Clinical signs, laboratory findings, and pancreas-associated variables were compared between groups, and the impact of possible AP on disease course, duration of hospitalization, and outcome was assessed. Results Serum Spec cPL concentration in 35 puppies was above the upper limit of the RI in 17/35 (48.6%) dogs (Group A) and within the RI in 18 dogs (Group B). An increased serum lipase activity was present in 29/35 (82.9%) dogs, and Group A dogs had a higher serum lipase activity than Group B (P = .006). Serum Spec cPL in Group A dogs was positively correlated with serum lipase activity at the day of presentation (r = .667; P = .003) and day of discharge (r = .628; P = .007). No statistically significant difference was found between groups (P = .233) for the presence of systemic inflammatory response syndrome (SIRS) (6/17 or 35.3% dogs Group A, and 8/18 or 44.4% dogs Group B), the disease course, duration of hospitalization, or outcome between groups. Conclusions Increased serum Spec cPL is relatively common in dogs with CPV enteritis. However, such increases do not seem to correlate with the outcome of disease. |
| Databáze: | OpenAIRE |
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