Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease

Autor: Ragnvi Hagman, T. Falk, Katja Höglund, Anna Hillström, Jacob E. Møller, Jens Häggström, Ingrid Ljungvall, Lisbeth H. Olsen, M.J. Reimann
Rok vydání: 2016
Předmět:
Male
Dog Diseases/blood
medicine.medical_specialty
040301 veterinary sciences
Heart Valve Diseases
Disease
030204 cardiovascular system & hematology
Asymptomatic
Group A
CRP Mitral regurgitation Dog Inflammation Valvular disease chronic valvular disease king-charles-spaniels flow-mediated vasodilation plasma-concentration risk-factors regurgitation severity echocardiography expression inflammation Veterinary Sciences
0403 veterinary science
C-Reactive Protein/analysis
03 medical and health sciences
Dogs
0302 clinical medicine
Internal medicine
Mitral valve
Dog
medicine
Heart Failure/blood
Animals
Heart Valve Diseases/complications
Dog Diseases
Mitral regurgitation
Heart Failure
Inflammation
General Veterinary
biology
business.industry
C-reactive protein
04 agricultural and veterinary sciences
Valvular disease
Mitral Valve/physiopathology
medicine.disease
C-Reactive Protein
medicine.anatomical_structure
Quartile
Heart failure
biology.protein
Cardiology
Mitral Valve
Female
Animal Science and Zoology
medicine.symptom
CRP
business
Zdroj: Reimann, M J, Ljungvall, I, Hillstrom, A, Moller, J E, Hagman, R, Falk, R T, Hoglund, K, Haggstrom, J & Olsen, L H 2016, ' Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease ', Veterinary Journal, vol. 209, pp. 113-118 . https://doi.org/10.1016/j.tvjl.2015.12.006
ISSN: 1090-0233
Popis: Cardiovascular disease in humans and dogs is associated with mildly increased circulating concentrations of C-reactive protein (CRP). Few studies have evaluated associations between circulating CRP and canine myxomatous mitral valve disease (MMVD) and the results reported have been divergent. The aim of this study was to investigate whether serum concentrations of CRP, determined using a novel automated canine-specific high-sensitivity CRP assay (Gentian hsCRP), were associated with severity of MMVD and selected clinical variables in dogs. The study included 188 client-owned dogs with different severities of MMVD. Dogs were classified based on ACVIM consensus statement guidelines (group A, n = 58; group B1, n = 56; group B2, n = 38; group C, n = 36). Data were analysed using descriptive statistics and multiple regression analysis. Dogs with congestive heart failure (CHF; group C) had significantly higher CRP concentrations (median, 2.65 mg/L; quartile 1-quartile 3, 1.09-5.09) compared to dogs in groups A (median, 0.97 mg/L; quartile 1-quartile 3, 2 = 0.07) and left ventricular end-diastolic diameter normalised for bodyweight (P = 0.0005, adjusted r 2 = 0.06), were positively associated with CRP concentration, but the association disappeared if dogs with CHF were excluded from analysis. In conclusion, slightly higher CRP concentrations were found in dogs with CHF whereas severity of asymptomatic MMVD showed no association with CRP concentrations.
Databáze: OpenAIRE
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