Spatial and Temporal Characteristics of Visual Field Progression in Glaucoma Assessed by Parallel Factor Analysis
| Autor: | Kilhwan Shon, Seungmo Kim, Kyung Rim Sung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Retinal Ganglion Cells medicine.medical_specialty Multi-way decomposition media_common.quotation_subject Glaucoma Refraction Ocular 03 medical and health sciences 0302 clinical medicine Ophthalmology medicine Contrast (vision) Humans Intraocular Pressure media_common Retrospective Studies business.industry General Medicine Middle Aged medicine.disease Visual field Visual fields 030221 ophthalmology & optometry Disease Progression Parallel factor analysis Visual Field Tests Original Article Female business Factor Analysis Statistical 030217 neurology & neurosurgery Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | Korean Journal of Ophthalmology : KJO |
| ISSN: | 2092-9382 1011-8942 |
| Popis: | PURPOSE To explore spatial and temporal characteristics of glaucomatous visual field (VF) progression through multi-way decomposition of data. METHODS Six serial VF exams with intervals of 6.0 ± 1.0 months in 121 pre-perimetric glaucoma eyes and 80 perimetric glaucoma eyes were arranged into a three-dimensional cube. The data were decomposed using parallel factor analysis. RESULTS Three tri-linear components (i.e., spatial scores, temporal loadings, and subject-specific loadings) were identified. Component 1 clearly showed differences between superior and inferior hemispheres, linear trends over time, and wide variability in perimetric glaucoma. Findings were compatible with well-known characteristics of glaucomatous VF defects. Component 2 showed nasal and central areas in contrast with superior, inferior, and temporal peripheral locations, whereas component 3 showed a contrast between nasal and temporal hemispheres. Both components 2 and 3 failed to show clear temporal trends. CONCLUSIONS Identification of spatio-temporal patterns shows new possibilities for a multi-way decomposition methodology for earlier diagnosis and prediction of glaucomatous VF progression. |
| Databáze: | OpenAIRE |
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