Synthesis and identification of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β,4′-oxazole] analogs with dissociated antiprogesterone activities
| Autor: | Margaret Kiddoe, Olivia Linton, C. Edgar Cook, John A. Kepler, Zhihua Sui, Sheela Bhattacharjee, George F. Allan, Scott G. Lundeen, Chunyang Jin, Govindarajan Manikumar |
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| Rok vydání: | 2007 |
| Předmět: |
Diene
Stereochemistry Aryl medicine.medical_treatment Antiglucocorticoid Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Chemical synthesis Combinatorial chemistry Cell Line Steroid chemistry.chemical_compound chemistry Drug Discovery Selective progesterone receptor modulator medicine Humans Molecular Medicine Alkaline phosphatase Oxazoles Molecular Biology Progesterone Oxazole |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 17:5754-5757 |
| ISSN: | 0960-894X |
| Popis: | A series of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β,4′-oxazole] analogs have been evaluated for their antagonist hormonal properties using the T47D cell-based alkaline phosphatase assay and the A549 cell-based functional assay. Some of the compounds showed highly potent, and more selective antiprogestational activity against antiglucocorticoid activity than mifepristone (RU 486). |
| Databáze: | OpenAIRE |
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