Prevalence of human papillomavirus (HPV), distribution of HPV types, and risk factors for infection in HPV-positive women
| Autor: | Luiz Antonio Ferreira da Silva, Ana Pavla Almeida Diniz Gurgel, A.C.F. Freitas, M.V.C. Santos Filho, C.D.P. Lobo, Jacinto da Costa Silva-Neto |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Genotype Population Uterine Cervical Neoplasms Cervix Uteri law.invention 03 medical and health sciences 0302 clinical medicine Risk Factors law Internal medicine Prevalence Genetics medicine Humans Papillomaviridae Human papillomavirus education Molecular Biology Polymerase chain reaction Vaginal Smears education.field_of_study 030219 obstetrics & reproductive medicine Hpv types biology business.industry Papillomavirus Infections virus diseases General Medicine Middle Aged biology.organism_classification Vaccination Family planning 030220 oncology & carcinogenesis DNA Viral Female business Brazil |
| Zdroj: | Genetics and Molecular Research. 15 |
| ISSN: | 1676-5680 |
| Popis: | The aim of this study was to describe the prevalence of human papillomavirus (HPV), the distribution of different HPV types, and the putative risk factors for infection among HPV-positive women from the State of Alagoas, Northeast Brazil. We analyzed data from 515 patients attending public and private health centers. HPV DNA from cervical samples was extracted and HPV genotyping was performed by polymerase chain reaction using MY09/11 consensus primers followed by direct sequencing. The chi-squared test for independence was used to assess statistical differences between the HPV groups. HPV DNA was found in 111 (21.55%) cervical samples. Twenty genotypes were detected: HPV6, 11, 16, 31, 33, 35, 39, 52, 53, 54, 58, 61, 62, 66, 70, 72, 81, 82, 83, and 84. In addition, multiple sexual partners (P = 0.002) and the use of oral contraceptives (P = 0.015) were associated with the presence of HPV. These findings may be relevant to the design of screening and vaccination strategies targeting specific groups of women in Northeast Brazil. |
| Databáze: | OpenAIRE |
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